Índice completo de variantes genéticas

Fast-twitch muscle fiber protein. R577X sprint gene.

Energy metabolism during exercise.

Red blood cell production for oxygen capacity.

Response to low oxygen. Altitude adaptation.

Lactate transport during exercise.

Muscle growth inhibitor. Less equals more muscle.

Converts pyridoxal phosphate to pyridoxal for cellular uptake.

Essential partner of cubilin for B12 absorption.

Metabolizes pyridoxal to 4-pyridoxic acid.

Converte beta-caroteno em vitamina A

Secondary pathway for carotenoid cleavage.

Receptor for intrinsic factor-B12 complex in ileum.

Inactivates vitamin D metabolites. Regulates vitamin D levels.

Kidney enzyme converting 25OHD to active 1,25OH2D.

Enzyme that activates vitamin D in the liver

Metabolizes vitamin E and vitamin K.

Provides precursor for vitamin D synthesis in skin.

Reduces dihydrofolate to tetrahydrofolate. Crucial for folate cycle.

Intestinal enzyme for dietary folate absorption.

Influencia a absorcao de B12 no intestino

Principal proteina de transporte da vitamina D no sangue

Vitamin K-dependent carboxylation of clotting factors.

Intrinsic factor production for B12 absorption.

Esterifies retinol for storage in liver.

Intracellular processing of B12.

Enzima-chave no metabolismo do folato e no ciclo de metilacao

Regenera metionina a partir da homocisteina utilizando vitamina B12

Mantém a enzima MTR em estado ativo

Associated with vitamin D levels.

Phosphorylates vitamin B6 vitamers to active forms.

Converts pyridoxine/pyridoxamine to active pyridoxal-5-phosphate.

Major transport protein for retinol in blood.

Reduced folate carrier for cellular folate uptake.

Transportador intestinal de vitamina C

SVCT2 - vitamin C transporter in various tissues.

Cellular receptor for retinol uptake from RBP4.

Haptocorrin - binds B12 in saliva and stomach.

Main transport protein for B12 delivery to tissues.

Liver protein regulating alpha-tocopherol blood levels.

Essential for DNA synthesis. Target of folate-related metabolism.

Recetor nuclear que medeia os efeitos da vitamina D

Recycles vitamin K for clotting factor activation.

Intestinal copper absorption and transport.

ATP7B encodes a copper-transporting ATPase that moves excess copper out of liver cells and into bile for excretion. Loss...

Magnesium transport in kidney.

Copper transport protein and ferroxidase.

Selenium-dependent thyroid hormone activation.

Converts T4 to active T3 in tissues.

Iron storage with ferroxidase activity.

Iron storage protein component.

Master regulator of iron absorption.

Regula a absorcao de ferro no intestino

Zinc binding and homeostasis protein.

Major metallothionein for zinc homeostasis.

Major selenium transport protein in blood.

Intestinal iron absorption transporter.

Transporta zinco para os granulos secretores das celulas beta pancreaticas

Major intestinal zinc absorption transporter.

Exports iron from cells to blood.

Active iodide transport into thyroid.

Main iron transport protein in blood.

Iron uptake in liver. Regulates hepcidin.

Precursor for thyroid hormone synthesis.

Regulates hepcidin. Matriptase-2.

Thyroid hormone synthesis enzyme.

Primary intestinal magnesium absorption channel.

Ubiquitous magnesium channel.

Epithelial calcium channel for absorption.

Intestinal calcium absorption channel.

Fructose metabolism enzyme. Hereditary fructose intolerance.

Immune regulation gene linked to celiac disease.

Celiac disease risk

Celiac disease risk

HLA-DQ2 DQ8 component for celiac disease risk.

HLA-DQ2 DQ8 component for celiac disease risk.

Enzyme that digests lactose (milk sugar)

Regula a expressao do gene da lactase (tolerancia a lactose)

Cilantro taste

Fructose transporter in intestine.

Oxidizes sulfite to sulfate. Essential detoxification.

Bitter taste perception

Sulfonylurea receptor. Insulin secretion.

Salivary amylase. Starch digestion. Copy number varies.

HDL component

Triglyceride metabolism

Sintetiza ácidos graxos ômega-3 de cadeia muito longa (EPA a DHA); marcador de metilação de DNA para o envelhecimento bi...

Envolvido na síntese de ácidos graxos de cadeia longa a partir de precursores C18 e C20; influencia o equilíbrio ômega-3...

Metabolismo dos acidos graxos omega-3 e omega-6

Enzyme involved in omega fatty acid metabolism

Glucose sensor in pancreas and liver. MODY2.

Transcription factor for insulin secretion. MODY3.

Glucose metabolism regulator. MODY1.

Insulin signaling cascade.

Insulin signaling in liver and beta cells.

Pancreatic beta cell potassium channel.

HDL metabolism

O PNPLA3 codifica uma enzima lipase que decompõe os triglicéridos armazenados nas células do fígado. Certas variantes pr...

Fat oxidation during exercise.

Master regulator of mitochondrial biogenesis.

Endurance training adaptation. Mitochondrial biogenesis.

Glucose transporter in liver and pancreas.

Insulin-responsive glucose transporter.

Principal fator de risco genetico para diabetes tipo 2

P-glycoprotein efflux pump. Drug transport.

Metabolizes polycyclic aromatic hydrocarbons.

Estrogen metabolism. Affects detox capacity.

Drug metabolism. Proton pump inhibitors.

Major drug metabolizing enzyme. Warfarin metabolism.

Metabolizes 25 percent of all drugs. Highly polymorphic.

Metabolizes 50 percent of all drugs. Major CYP enzyme.

Additional drug metabolism pathway.

Detoxification enzyme important for antioxidant defense

Enzima de destoxificacao de fase II que conjuga glutationa a toxinas

Detoxification enzyme important for toxin elimination

Acetylation of drugs and carcinogens.

Enzima de fase II que metaboliza aminas aromaticas e isoniazida

Desintoxica quinonas e protege contra o estresse oxidativo

Sulfation of phenols and estrogens.

Bilirubin conjugation. Gilbert syndrome.

Leukotriene synthesis. Inflammation pathway.

Inflammatory marker. Cardiovascular risk.

Th1 cytokine. Immune activation.

Anti-inflammatory cytokine.

Major pro-inflammatory cytokine.

Th2 cytokine. Allergies and atopy.

Regula a inflamação aguda e as respostas imunes; influencia a regeneração muscular e a sensibilidade à insulina

Master inflammatory transcription factor.

Principal citocina pró-inflamatória; regula a inflamação sistêmica e a defesa imune

Converts hydrogen peroxide to water.

Reduz hidroperóxidos com glutationa; proteção contra danos oxidativos pelo selênio

Lipid-specific selenoprotein antioxidant.

Cytoplasmic antioxidant enzyme.

Neutraliza radicais superóxido nas mitocôndrias; proteção contra estresse oxidativo

Caffeine blocks this receptor. Affects sensitivity.

Induces CYP1A2 expression.

Principal enzima para o metabolismo da cafeina

Primeira etapa do metabolismo do alcool

Additional alcohol dehydrogenase isoform.

Stomach alcohol metabolism.

Converte acetaldeido em acetato

Alternative alcohol metabolism pathway.

Insulin sensitivity and fat metabolism hormone.

Receptor involved in bronchodilation and fat metabolism

Brown fat thermogenesis receptor.

Influencia a regulacao do apetite e o armazenamento de gordura

Hunger hormone.

Satiety hormone from fat tissue.

Hypothalamic leptin signaling.

Central appetite regulation. Satiety signaling.

Potent appetite stimulant.

Precursor for satiety signals alpha-MSH.

Regulador principal da diferenciacao de celulas adiposas e sensibilidade a insulina

Strongly associated with BMI.

Brown fat thermogenesis protein.

Energy expenditure regulation.

Muscle energy expenditure.

Reverse cholesterol transport. HDL formation.

Converte angiotensina I em II; regula a pressao arterial

I D polymorphism affects endurance vs power.

Salt-sensitive blood pressure gene.

Precursor in blood pressure regulation.

Inhibits LPL. Regulates triglycerides.

Inhibits LPL in fasting state.

Main protein of HDL. Cardioprotective.

Main protein of LDL. Familial hypercholesterolemia gene.

Inhibits lipoprotein lipase. Affects triglycerides.

Metabolismo dos lipidos e saude cardiovascular

Transfere esteres de colesterol entre particulas HDL e LDL

Rate-limiting enzyme in cholesterol synthesis. Statin target.

Clears LDL from blood. Familial hypercholesterolemia.

Breaks down triglycerides in lipoproteins.

Produces NO for vasodilation.

Vasodilation and blood flow during exercise.

Intestinal cholesterol absorption. Ezetimibe target.

Regula a degradacao do receptor LDL e os niveis de LDL-colesterol

Antioxidant enzyme

Angiogenesis for endurance adaptation.

Receptor sensor de cálcio no sangue; regula a secreção de paratormônio e a homeostase do cálcio

Bone and tendon structure. Injury risk.

Tendon and ligament injury risk.

Joint and cartilage development. Injury risk.

Converte homocisteína em metionina; via alternativa de metilação independente de B12

Converte homocisteína em cistationina; primeiro passo da via de transsulfuração

Oxidizes choline to betaine aldehyde.

Sintetiza fosfatidilcolina de novo; importante para a saúde hepática e o desenvolvimento de membranas fetais

Interconverts serine and glycine with THF. Key for one-carbon metabolism.

Principal enzima para degradação de histamina no intestino; influencia intolerância à histamina e reações alérgicas

Inativa histamina por N-metilação intracelular; complementar à DAO extracelular

Principal regulador do ritmo circadiano; influencia o ciclo sono-vigília, o metabolismo e a secreção hormonal

Core circadian rhythm gene.

Sleep timing

Supports neuron survival and growth. Val66Met affects memory.

Degrada catecolaminas (dopamina, adrenalina, noradrenalina); influencia humor, cognição e resposta ao estresse

Dopamine reuptake. ADHD medication target.

Major dopamine receptor. Affects reward sensitivity.

Linked to novelty seeking and ADHD.

GABA receptor affecting anxiety and alcohol response.

Synthesizes GABA from glutamate.

Major serotonin receptor. Affects mood and appetite.

Degrada serotonina, dopamina e noradrenalina. O «gene do guerreiro».

Primarily degrades dopamine and phenylethylamine.

Serotonin reuptake. SSRI target. Short Long alleles.

Rate-limiting enzyme in dopamine synthesis.

Peripheral serotonin synthesis.

Brain serotonin synthesis.