Índice completo de variantes genéticas

Fast-twitch muscle fiber protein. R577X sprint gene.

Converts pyridoxal phosphate to pyridoxal for cellular uptake.

Essential partner of cubilin for B12 absorption.

Metabolizes pyridoxal to 4-pyridoxic acid.

Secondary pathway for carotenoid cleavage.

Supports neuron survival and growth. Val66Met affects memory.

Oxidizes choline to betaine aldehyde.

Tendon and ligament injury risk.

Receptor for intrinsic factor-B12 complex in ileum.

Inactivates vitamin D metabolites. Regulates vitamin D levels.

Kidney enzyme converting 25OHD to active 1,25OH2D.

Metabolizes vitamin E and vitamin K.

Reduces dihydrofolate to tetrahydrofolate. Crucial for folate cycle.

Converts T4 to active T3 in tissues.

Intestinal enzyme for dietary folate absorption.

Vitamin K-dependent carboxylation of clotting factors.

Intrinsic factor production for B12 absorption.

Esterifies retinol for storage in liver.

Intracellular processing of B12.

Enzima-chave no metabolismo do folato e no ciclo de metilacao

Mantém a enzima MTR em estado ativo

Associated with vitamin D levels.

Phosphorylates vitamin B6 vitamers to active forms.

Sintetiza fosfatidilcolina de novo; importante para a saúde hepática e o desenvolvimento de membranas fetais

Sleep timing

Converts pyridoxine/pyridoxamine to active pyridoxal-5-phosphate.

Major transport protein for retinol in blood.

Interconverts serine and glycine with THF. Key for one-carbon metabolism.

Reduced folate carrier for cellular folate uptake.

Transportador intestinal de vitamina C

SVCT2 - vitamin C transporter in various tissues.

Cellular receptor for retinol uptake from RBP4.

Haptocorrin - binds B12 in saliva and stomach.

Liver protein regulating alpha-tocopherol blood levels.

Essential for DNA synthesis. Target of folate-related metabolism.

Recetor nuclear que medeia os efeitos da vitamina D

Recycles vitamin K for clotting factor activation.

Intestinal copper absorption and transport.

Copper excretion in liver. Wilson disease gene.

Converte beta-caroteno em vitamina A

Receptor sensor de cálcio no sangue; regula a secreção de paratormônio e a homeostase do cálcio

Magnesium transport in kidney.

Copper transport protein and ferroxidase.

Enzyme that activates vitamin D in the liver

Provides precursor for vitamin D synthesis in skin.

Selenium-dependent thyroid hormone activation.

Iron storage with ferroxidase activity.

Iron storage protein component.

Influencia a absorcao de B12 no intestino

Principal proteina de transporte da vitamina D no sangue

Reduz hidroperóxidos com glutationa; proteção contra danos oxidativos pelo selênio

Lipid-specific selenoprotein antioxidant.

Master regulator of iron absorption.

Zinc binding and homeostasis protein.

Major metallothionein for zinc homeostasis.

Regenera metionina a partir da homocisteina utilizando vitamina B12

Major selenium transport protein in blood.

Intestinal iron absorption transporter.

Major intestinal zinc absorption transporter.

Exports iron from cells to blood.

Active iodide transport into thyroid.

Iron uptake in liver. Regulates hepcidin.

Precursor for thyroid hormone synthesis.

Thyroid hormone synthesis enzyme.

Primary intestinal magnesium absorption channel.

Ubiquitous magnesium channel.

Epithelial calcium channel for absorption.

Intestinal calcium absorption channel.

Fructose metabolism enzyme. Hereditary fructose intolerance.

Diamine oxidase - degrades histamine in gut.

Converte homocisteína em cistationina; primeiro passo da via de transsulfuração

Immune regulation gene linked to celiac disease.

Regula a absorcao de ferro no intestino

Inativa histamina por N-metilação intracelular; complementar à DAO extracelular

Enzyme that digests lactose (milk sugar)

Regula a expressao do gene da lactase (tolerancia a lactose)

Fructose transporter in intestine.

Transporta zinco para os granulos secretores das celulas beta pancreaticas

Oxidizes sulfite to sulfate. Essential detoxification.

Main iron transport protein in blood.

Regulates hepcidin. Matriptase-2.

P-glycoprotein efflux pump. Drug transport.

Converts hydrogen peroxide to water.

Metabolizes polycyclic aromatic hydrocarbons.

Drug metabolism. Proton pump inhibitors.

Major drug metabolizing enzyme. Warfarin metabolism.

Metabolizes 25 percent of all drugs. Highly polymorphic.

Metabolizes 50 percent of all drugs. Major CYP enzyme.

Additional drug metabolism pathway.

Principal enzima para degradação de histamina no intestino; influencia intolerância à histamina e reações alérgicas

Detoxification enzyme important for antioxidant defense

Detoxification enzyme important for toxin elimination

Celiac disease risk

Celiac disease risk

HLA-DQ2 DQ8 component for celiac disease risk.

HLA-DQ2 DQ8 component for celiac disease risk.

Acetylation of drugs and carcinogens.

Desintoxica quinonas e protege contra o estresse oxidativo

Cilantro taste

Cytoplasmic antioxidant enzyme.

Neutraliza radicais superóxido nas mitocôndrias; proteção contra estresse oxidativo

Sulfation of phenols and estrogens.

Bitter taste perception

Bilirubin conjugation. Gilbert syndrome.

HDL component

Triglyceride metabolism

Principal regulador do ritmo circadiano; influencia o ciclo sono-vigília, o metabolismo e a secreção hormonal

Degrada catecolaminas (dopamina, adrenalina, noradrenalina); influencia humor, cognição e resposta ao estresse

Dopamine reuptake. ADHD medication target.

Linked to novelty seeking and ADHD.

Metabolismo dos acidos graxos omega-3 e omega-6

Enzyme involved in omega fatty acid metabolism

GABA receptor affecting anxiety and alcohol response.

Synthesizes GABA from glutamate.

Major serotonin receptor. Affects mood and appetite.

Insulin signaling cascade.

HDL metabolism

Degrades serotonin dopamine norepinephrine. Warrior gene.

Primarily degrades dopamine and phenylethylamine.

Core circadian rhythm gene.

Antioxidant enzyme

Regulador principal da diferenciacao de celulas adiposas e sensibilidade a insulina

Serotonin reuptake. SSRI target. Short Long alleles.

Principal fator de risco genetico para diabetes tipo 2

Rate-limiting enzyme in dopamine synthesis.

Peripheral serotonin synthesis.

Brain serotonin synthesis.

Leukotriene synthesis. Inflammation pathway.

Estrogen metabolism. Affects detox capacity.

Enzima de destoxificacao de fase II que conjuga glutationa a toxinas

Th1 cytokine. Immune activation.

Anti-inflammatory cytokine.

Major pro-inflammatory cytokine.

Th2 cytokine. Allergies and atopy.

Enzima de fase II que metaboliza aminas aromaticas e isoniazida

Master inflammatory transcription factor.

Principal citocina pró-inflamatória; regula a inflamação sistêmica e a defesa imune

Sulfonylurea receptor. Insulin secretion.

Salivary amylase. Starch digestion. Copy number varies.

Inflammatory marker. Cardiovascular risk.

Glucose sensor in pancreas and liver. MODY2.

Transcription factor for insulin secretion. MODY3.

Glucose metabolism regulator. MODY1.

Regula a inflamação aguda e as respostas imunes; influencia a regeneração muscular e a sensibilidade à insulina

Insulin signaling in liver and beta cells.

Pancreatic beta cell potassium channel.

Master regulator of mitochondrial biogenesis.

Glucose transporter in liver and pancreas.

Insulin-responsive glucose transporter.

Primeira etapa do metabolismo do alcool

Additional alcohol dehydrogenase isoform.

Stomach alcohol metabolism.

Caffeine blocks this receptor. Affects sensitivity.

Induces CYP1A2 expression.

Converte acetaldeido em acetato

Principal enzima para o metabolismo da cafeina

Alternative alcohol metabolism pathway.

Brown fat thermogenesis receptor.

Hunger hormone.

Satiety hormone from fat tissue.

Potent appetite stimulant.

Precursor for satiety signals alpha-MSH.

Strongly associated with BMI.

Brown fat thermogenesis protein.

Energy expenditure regulation.

Muscle energy expenditure.

Reverse cholesterol transport. HDL formation.

Converte angiotensina I em II; regula a pressao arterial

Salt-sensitive blood pressure gene.

Insulin sensitivity and fat metabolism hormone.

Receptor involved in bronchodilation and fat metabolism

Precursor in blood pressure regulation.

Inhibits LPL. Regulates triglycerides.

Inhibits LPL in fasting state.

Main protein of HDL. Cardioprotective.

Main protein of LDL. Familial hypercholesterolemia gene.

Inhibits lipoprotein lipase. Affects triglycerides.

Metabolismo dos lipidos e saude cardiovascular

Major dopamine receptor. Affects reward sensitivity.

Sintetiza ácidos graxos ômega-3 de cadeia muito longa (EPA a DHA); marcador de metilação de DNA para o envelhecimento bi...

Envolvido na síntese de ácidos graxos de cadeia longa a partir de precursores C18 e C20; influencia o equilíbrio ômega-3...

Influencia a regulacao do apetite e o armazenamento de gordura

Rate-limiting enzyme in cholesterol synthesis. Statin target.

Clears LDL from blood. Familial hypercholesterolemia.

Hypothalamic leptin signaling.

Breaks down triglycerides in lipoproteins.

Central appetite regulation. Satiety signaling.

Produces NO for vasodilation.

Intestinal cholesterol absorption. Ezetimibe target.

Regula a degradacao do receptor LDL e os niveis de LDL-colesterol

I D polymorphism affects endurance vs power.

Energy metabolism during exercise.

Transfere esteres de colesterol entre particulas HDL e LDL

Bone and tendon structure. Injury risk.

Red blood cell production for oxygen capacity.

Joint and cartilage development. Injury risk.

Response to low oxygen. Altitude adaptation.

Lactate transport during exercise.

Muscle growth inhibitor. Less equals more muscle.

Vasodilation and blood flow during exercise.

Fat oxidation during exercise.

Endurance training adaptation. Mitochondrial biogenesis.

Angiogenesis for endurance adaptation.

Converte homocisteína em metionina; via alternativa de metilação independente de B12

Main transport protein for B12 delivery to tissues.