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Folate-dependent one-carbon metabolism (DNA synthesis and methylation)
| Genotype | Impact | What it means |
|---|---|---|
| GG (Normal) | Normal | Normal MTHFD1 activity, efficient folate-dependent one-carbon metabolism (DNA synthesis and methylation). Maintain folate-rich foods (leafy greens, legumes). |
| GA (Carrier) | Low impact | Slightly reduced MTHFD1 stability, modestly higher folate demand. Ensure good natural folate intake (leafy greens, legumes); relevant alongside MTHFR variants and in pregnancy. |
| AA (Variant) | Moderate | Reduced MTHFD1 activity, higher folate requirement for DNA synthesis and methylation. Prioritise natural folate (and methylfolate if combined with MTHFR variants); especially important before and during pregnancy. |
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