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Induces CYP1A2 expression.
iHow to read this: each row is one possible genotype, the two DNA letters you carry at this position, one inherited from each parent. "Normal" matches the more common version; "Carrier" (heterozygous) means you have one copy of each version, usually a partial effect; "Variant" (homozygous) means both copies carry the less common version, usually the strongest effect. The estimated frequency below is calculated from the variant's frequency in the general population (Hardy-Weinberg principle) — it is a population estimate, not a measurement of our own customers.
| Genotype | Impact | Est. frequency | What it means |
|---|---|---|---|
| CCNormal | Normal | ~36% | Higher CYP1A2 induction: faster caffeine metabolism. You generally tolerate coffee well; keep it before mid-afternoon. |
| CTCarrier | Low impact | ~48% | Intermediate CYP1A2 induction: average caffeine clearance. Watch afternoon coffee if it affects your sleep. |
| TTVariant | Moderate | ~16% | Lower CYP1A2 induction: slower caffeine processing. Limit caffeine to the morning; green tea (with L-theanine) is a gentler option. |
Estimated with the Hardy-Weinberg principle from the variant's population frequency, not measured directly.
| Genotype | Impact | Est. frequency | What it means |
|---|---|---|---|
| GGNormal | Normal | ~77% | Normal CYP1A2 induction: standard caffeine and xenobiotic processing. |
| GACarrier | Low impact | ~21% | Reduced enzyme induction: slower response to dietary/environmental inducers; caffeine may clear a bit more slowly. Keep caffeine moderate. |
| AAVariant | Moderate | ~1% | Lower CYP1A2 expression and slower caffeine metabolism. Favour morning-only caffeine and watch your individual response. |
Estimated with the Hardy-Weinberg principle from the variant's population frequency, not measured directly.
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