Alcohol Metabolism

ALDH2 Aldehyde Dehydrogenase 2

Enzyme that metabolizes acetaldehyde from alcohol

Chromosome
12
Variants read
1
Foods
0
Fig. 1Position of ALDH2 on chromosome 12 approximate, banding stylised
ALDH2 · rs671
0 Mb · p armcentromereq arm · 134 Mb
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Gene function

Breaks down toxic acetaldehyde produced during alcohol metabolism

Analyzed variants (SNPs)

How to read this: each row is one possible genotype, the two DNA letters you carry at this position, one inherited from each parent. "Normal" matches the more common version; "Carrier" (heterozygous) means you have one copy of each version, usually a partial effect; "Variant" (homozygous) means both copies carry the less common version, usually the strongest effect. The estimated frequency below is calculated from the variant's frequency in the general population (Hardy-Weinberg principle) — it is a population estimate, not a measurement of our own customers.

rs671 ALDH2-2 Glu504Lys Population frequency: 18.0% Chr. 12 : 112,241,766
Genotype Impact Est. frequency What it means
GGNormal Normal ~67% Normal alcohol metabolism.
GACarrier High impact ~30% Reduced alcohol metabolism. May experience flushing with alcohol.
AAVariant Very high ~3% Very poor alcohol metabolism. Strong flushing reaction. Avoid or strictly limit alcohol.

Estimated with the Hardy-Weinberg principle from the variant's population frequency, not measured directly.

Related reading

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