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Reduced folate carrier for cellular folate uptake.
iHow to read this: each row is one possible genotype, the two DNA letters you carry at this position, one inherited from each parent. "Normal" matches the more common version; "Carrier" (heterozygous) means you have one copy of each version, usually a partial effect; "Variant" (homozygous) means both copies carry the less common version, usually the strongest effect. The estimated frequency below is calculated from the variant's frequency in the general population (Hardy-Weinberg principle) — it is a population estimate, not a measurement of our own customers.
| Genotype | Impact | Est. frequency | What it means |
|---|---|---|---|
| GGNormal | Normal | ~27% | Normal cellular folate transport: folate enters cells efficiently. Maintain folate-rich foods (leafy greens, legumes). |
| GACarrier | Low impact | ~50% | Reduced cellular folate uptake: slightly lower folate inside cells. Increase natural folate and consider methylfolate if combined with MTHFR variants. |
| AAVariant | Moderate | ~23% | Significantly reduced folate transport: lower intracellular folate. Prioritise leafy greens and legumes; methylfolate may help, especially alongside MTHFR variants. |
Estimated with the Hardy-Weinberg principle from the variant's population frequency, not measured directly.
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