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FADS1
Fatty Acid Desaturase 1
Metabolic Health & Glycemia Chr. 11 3 SNPs analyzed 9 food interactions

About this gene

Enzyme involved in omega fatty acid metabolism

Gene function

Converts dietary fatty acids to longer-chain omega-3 and omega-6

Analyzed variants (SNPs)

rs174547 FADS1 Population frequency: 35.0%
Genotype Impact What it means
TT (Normal) Normal Efficient omega-3 conversion from plant sources (ALA to EPA/DHA).
TC (Carrier) Low impact Moderate omega-3 conversion. Mix of plant and marine omega-3 sources recommended.
CC (Variant) Moderate Poor omega-3 conversion. Direct sources (fatty fish, fish oil) recommended over plant sources.
rs174537 FADS1 rs174537 Population frequency: 33.0% Chr. 11 : 61,552,680

FADS1 variant affecting omega-3/omega-6 conversion

Genotype Impact What it means
GG (Normal) Normal Efficient omega-3 conversion from plant sources (ALA to EPA/DHA).
GT (Carrier) Low impact Moderate omega-3 conversion. Mix of plant and marine omega-3 sources recommended.
TT (Variant) Moderate Poor omega-3 conversion. Direct sources (fatty fish, fish oil) recommended over plant sources.
rs174546 FADS1 rs174546 Population frequency: 35.0% Chr. 11 : 61,569,830
Genotype Impact What it means
CC (Normal) Normal Efficient omega-3 conversion from plant sources (ALA to EPA/DHA).
CT (Carrier) Low impact Moderate omega-3 conversion. Mix of plant and marine omega-3 sources recommended.
TT (Variant) Moderate Poor omega-3 conversion. Direct sources (fatty fish, fish oil) recommended over plant sources.
📄 PubMed 16635265 🔗 Source study

Foods & nutrition for FADS1

Beneficial foods

Beneficial foods
Wild Salmon
Pre-formed EPA/DHA bypasses conversion issues
Beneficial foods
Anchovy
Rich in omega-3 fatty acids
Beneficial foods
Mackerel
High in EPA/DHA
Beneficial foods
Sardines
Direct source of EPA/DHA
Beneficial foods
Mackerel
High in EPA/DHA
Beneficial foods
Anchovy
Rich in omega-3 fatty acids
Beneficial foods
Herring
Good preformed omega-3 source
Beneficial foods
Herring
Good preformed omega-3 source

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