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Enzyme involved in omega fatty acid metabolism
Converts dietary fatty acids to longer-chain omega-3 and omega-6
iHow to read this: each row is one possible genotype, the two DNA letters you carry at this position, one inherited from each parent. "Normal" matches the more common version; "Carrier" (heterozygous) means you have one copy of each version, usually a partial effect; "Variant" (homozygous) means both copies carry the less common version, usually the strongest effect. The estimated frequency below is calculated from the variant's frequency in the general population (Hardy-Weinberg principle) — it is a population estimate, not a measurement of our own customers.
Tags the same functional FADS1 haplotype as rs174546; studied alongside it for its effect on blood fatty-acid and oxylipin profiles.
| Genotype | Impact | Est. frequency | What it means |
|---|---|---|---|
| TTNormal | Normal | ~42% | Efficient omega-3 conversion from plant sources (ALA to EPA/DHA). |
| TCCarrier | Low impact | ~45% | Moderate omega-3 conversion. Mix of plant and marine omega-3 sources recommended. |
| CCVariant | Moderate | ~12% | Poor omega-3 conversion. Direct sources (fatty fish, fish oil) recommended over plant sources. |
Estimated with the Hardy-Weinberg principle from the variant's population frequency, not measured directly.
FADS1 variant affecting omega-3/omega-6 conversion
| Genotype | Impact | Est. frequency | What it means |
|---|---|---|---|
| GGNormal | Normal | ~45% | Efficient omega-3 conversion from plant sources (ALA to EPA/DHA). |
| GTCarrier | Low impact | ~44% | Moderate omega-3 conversion. Mix of plant and marine omega-3 sources recommended. |
| TTVariant | Moderate | ~11% | Poor omega-3 conversion. Direct sources (fatty fish, fish oil) recommended over plant sources. |
Estimated with the Hardy-Weinberg principle from the variant's population frequency, not measured directly.
Functional FADS1 3'UTR variant that creates a binding site for microRNA miR-149-5p. The minor allele lowers FADS1 (delta-5 desaturase) activity, shifting the balance toward more omega-3/omega-6 precursors (ALA, linoleic acid) and less arachidonic acid and EPA.
| Genotype | Impact | Est. frequency | What it means |
|---|---|---|---|
| CCNormal | Normal | ~42% | Efficient omega-3 conversion from plant sources (ALA to EPA/DHA). |
| CTCarrier | Low impact | ~45% | Moderate omega-3 conversion. Mix of plant and marine omega-3 sources recommended. |
| TTVariant | Moderate | ~12% | Poor omega-3 conversion. Direct sources (fatty fish, fish oil) recommended over plant sources. |
Estimated with the Hardy-Weinberg principle from the variant's population frequency, not measured directly.
How to get and read your raw DNA file
Upload your 23andMe or AncestryDNA file and get a personalized nutrition plan based on your exact genotype.