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COMT
Catechol-O-Methyltransferase
Metabolic Health & Glycemia Chr. 22 2 SNPs analyzed 2 food interactions

About this gene

Enzyme that breaks down catecholamines (dopamine, epinephrine)

Gene function

Regulates dopamine levels in the brain, affects stress response

Analyzed variants (SNPs)

rs4633 COMT rs4633 Population frequency: 47.0% Chr. 22 : 19,963,684
Genotype Impact What it means
CC (Normal) Normal Warrior type, fast dopamine breakdown, better stress resilience.
CT (Carrier) Low impact Balanced dopamine metabolism, moderate stress response and cognitive flexibility.
TT (Variant) Moderate Worrier type, slower dopamine breakdown, better focus but more stress sensitive. Magnesium helpful.
rs4680 Val158Met Population frequency: 47.0% Chr. 22 : 19,963,748

COMT variant affecting dopamine metabolism and stress response

Genotype Impact What it means
GG (Normal) Normal Warrior type, fast dopamine breakdown, better stress resilience.
GA (Carrier) Low impact Balanced dopamine metabolism, moderate stress response and cognitive flexibility.
AA (Variant) Moderate Worrier type, slower dopamine breakdown, better focus but more stress sensitive. Magnesium helpful.
📄 PubMed 9170756 🔗 Source study

Foods & nutrition for COMT

Beneficial foods

Beneficial foods
Eggs
Choline supports methylation pathways

Use with caution

Use with caution
Green Tea
EGCG inhibits COMT, may increase catecholamines in slow metabolizers

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