Caffeine blocks this receptor. Affects sensitivity.
| Genotype | Impact | What it means |
|---|---|---|
| TT (Normal) | Normal | Normal caffeine sensitivity |
| TC (Carrier) | Low impact | Increased anxiety response to caffeine. Consider reducing intake or switching to green tea (L-theanine buffers caffeine effect). |
| CC (Variant) | Moderate | High caffeine sensitivity, slow caffeine clearance can cause anxiety, jitters and insomnia. Limit caffeine to morning hours and consider <100 mg/day. |
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