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Maintains MTR enzyme in its active state. Essential for B12-dependent reactions.
| Genotype | Impact | What it means |
|---|---|---|
| AA (Normal) | Normal | Efficient methionine-synthase recycling - supports B12-dependent methylation. Maintain B12 intake (eggs, fish, meat). |
| AG (Carrier) | Low impact | Moderately reduced recycling of B12 in the methylation cycle - slightly higher B12 demand. Ensure regular B12 and folate; consider methylcobalamin if levels are low. |
| GG (Variant) | Moderate | Reduced B12 recycling - higher need for B12 and folate to keep homocysteine in check. Prioritise B12-rich foods or methylcobalamin and monitor B12/homocysteine. |
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