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MCM6
Lactase Persistence Regulator
Food Intolerances Chr. 2 2 SNPs analyzed

About this gene

Regulates lactase gene expression in adults

Gene function

Controls whether lactase production continues into adulthood

Analyzed variants (SNPs)

rs4988235 LCT-13910 Population frequency: 25.0% Chr. 2 : 136,608,646

Main MCM6 regulatory variant (LCT -13910C>T) determining lactase persistence in adults. The derived A allele (T on forward strand) confers lifelong lactose tolerance; the ancestral G allele is associated with lactase non-persistence.

Genotype Impact What it means
GG (Normal) High impact Lactose intolerant, lactase non-persistence (ancestral GG genotype). Consider lactose-free alternatives or lactase supplements.
GA (Carrier) Low impact Lactase persistent (one persistence allele) - your genes let you keep digesting lactose into adulthood, so genetic (primary) lactose intolerance is unlikely. Important: a DNA test only detects the genetic form. It cannot rule out acquired (secondary) lactose intolerance from age, gut issues or illness, which can affect anyone.
AA (Variant) Normal Lactase persistent (both persistence alleles) - you are genetically well-equipped to digest lactose into adulthood. Important: this is a genetic result only. Acquired (secondary) lactose intolerance from age, gut issues or illness is not detectable by DNA and can still occur.
📄 PubMed 12369545 🔗 Source study
rs182549 LCT -22018G-A Population frequency: 24.0% Chr. 2 : 136,616,754
Genotype Impact What it means
CC (Normal) Moderate Lactose intolerant, second LCT variant confirming lactase non-persistence.
CT (Carrier) Low impact Second LCT marker (partial) - consistent with lactase persistence. Note: a DNA test only detects genetic (primary) lactose intolerance; it cannot rule out acquired (secondary) intolerance from age, gut issues or illness, which can affect anyone.
TT (Variant) Normal Second LCT marker confirms lactase persistence - genetically you can digest lactose into adulthood. Note: this is a genetic result only; acquired (secondary) lactose intolerance from age, gut issues or illness is not detectable by DNA and can still occur.

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