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Converts T4 to active T3 in tissues.
| Genotype | Impact | What it means |
|---|---|---|
| CC (Normal) | High impact | Ala/Ala, reduced T4→T3 conversion. May benefit from selenium (~200 mcg/day) and adequate zinc; discuss thyroid panel with your doctor. |
| CT (Carrier) | Low impact | Reduced deiodinase activity, slower conversion of T4 to active T3. Ensure adequate selenium and zinc intake to support thyroid hormone activation. |
| TT (Variant) | Normal | Thr/Thr, normal T4→T3 conversion. No specific genetic concern. |
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