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Estrogen metabolism. Affects detox capacity.
| Genotype | Impact | What it means |
|---|---|---|
| CC (Normal) | Normal | Normal estrogen metabolism |
| CG (Carrier) | Low impact | Leu/Val heterozygote, altered phase I metabolism of xenobiotics and estrogens. Cruciferous vegetables (broccoli, cabbage, kale) support balanced phase II conjugation. |
| GG (Variant) | Moderate | Val/Val genotype, elevated 4-hydroxy-estrogen metabolites, higher oestrogen-related cancer risk. DIM and indole-3-carbinol (cruciferous vegetables) support healthier estrogen metabolism. |
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