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Converts pyridoxal phosphate to pyridoxal for cellular uptake.
iHow to read this: each row is one possible genotype, the two DNA letters you carry at this position, one inherited from each parent. "Normal" matches the more common version; "Carrier" (heterozygous) means you have one copy of each version, usually a partial effect; "Variant" (homozygous) means both copies carry the less common version, usually the strongest effect. The estimated frequency below is calculated from the variant's frequency in the general population (Hardy-Weinberg principle) — it is a population estimate, not a measurement of our own customers.
GWAS variant near NBPF3/AGPAT1 locus consistently associated with lower plasma pyridoxal-5-phosphate (PLP) levels. PLP is the active coenzyme form of vitamin B6 required for over 100 enzymatic reactions including homocysteine metabolism.
| Genotype | Impact | Est. frequency | What it means |
|---|---|---|---|
| CCNormal | Normal | ~46% | Normal pyridoxal-5-phosphate (PLP) plasma levels. Standard dietary B6 intake from meat, fish, and potatoes is generally sufficient. |
| CTCarrier | Low impact | ~44% | Moderately reduced PLP plasma levels tendency. Slightly elevated dietary B6 needs, prioritise B6-rich foods. Consider active pyridoxal-5-phosphate (P5P) supplementation over pyridoxine. |
| TTVariant | Moderate | ~10% | Consistently lower plasma vitamin B6 (PLP) levels. Higher dietary B6 requirements. Supplementation with the active P5P form is preferred over standard pyridoxine hydrochloride. Relevant interactions with MTHFR, CBS, and BHMT. |
Estimated with the Hardy-Weinberg principle from the variant's population frequency, not measured directly.
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