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Converts pyridoxal phosphate to pyridoxal for cellular uptake.
GWAS variant near NBPF3/AGPAT1 locus consistently associated with lower plasma pyridoxal-5-phosphate (PLP) levels. PLP is the active coenzyme form of vitamin B6 required for over 100 enzymatic reactions including homocysteine metabolism.
| Genotype | Impact | What it means |
|---|---|---|
| CC (Normal) | Normal | Normal pyridoxal-5-phosphate (PLP) plasma levels. Standard dietary B6 intake from meat, fish, and potatoes is generally sufficient. |
| CT (Carrier) | Low impact | Moderately reduced PLP plasma levels tendency. Slightly elevated dietary B6 needs, prioritise B6-rich foods. Consider active pyridoxal-5-phosphate (P5P) supplementation over pyridoxine. |
| TT (Variant) | Moderate | Consistently lower plasma vitamin B6 (PLP) levels. Higher dietary B6 requirements. Supplementation with the active P5P form is preferred over standard pyridoxine hydrochloride. Relevant interactions with MTHFR, CBS, and BHMT. |
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