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CYP1A2
Cytochrome P450 1A2
Caffeine Metabolism Chr. 15 1 SNP analyzed 6 food interactions

About this gene

Liver enzyme responsible for caffeine metabolism

Gene function

Metabolizes caffeine, certain drugs, and environmental toxins

Analyzed variants (SNPs)

rs762551 CYP1A2*1F Population frequency: 45.0% Chr. 15 : 75,041,917

Main variant determining caffeine metabolism speed

Genotype Impact What it means
AA (Normal) Normal Fast caffeine metabolizer. Can typically consume caffeine without adverse effects.
AC (Carrier) Moderate Moderate caffeine metabolizer. May want to limit afternoon caffeine for better sleep.
CC (Variant) High impact Slow caffeine metabolizer. Limit caffeine intake, especially after noon.
📄 PubMed 10090466 🔗 Source study

Foods & nutrition for CYP1A2

Use with caution

Use with caution
Matcha
Contains caffeine but with L-theanine
Use with caution
Matcha
Contains caffeine but with L-theanine
Use with caution
Coffee
Slow metabolizers should limit caffeine intake
Use with caution
Espresso
High caffeine concentration
Use with caution
Espresso
High caffeine concentration

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