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Intracellular histamine degradation.
iHow to read this: each row is one possible genotype, the two DNA letters you carry at this position, one inherited from each parent. "Normal" matches the more common version; "Carrier" (heterozygous) means you have one copy of each version, usually a partial effect; "Variant" (homozygous) means both copies carry the less common version, usually the strongest effect. The estimated frequency below is calculated from the variant's frequency in the general population (Hardy-Weinberg principle) — it is a population estimate, not a measurement of our own customers.
| Genotype | Impact | Est. frequency | What it means |
|---|---|---|---|
| CCNormal | Normal | ~81% | Normal HNMT activity: histamine is broken down efficiently inside cells. No special restriction needed. |
| CTCarrier | Low impact | ~18% | Moderately reduced HNMT activity: slightly slower histamine clearance. Limit very high-histamine foods (aged cheese, cured meats, wine) if you notice symptoms; ensure adequate vitamin C and B6. |
| TTVariant | Moderate | ~1% | Low HNMT activity: histamine sensitivity likely. Favour a lower-histamine diet (fresh foods, avoid aged/fermented items), support with vitamin C, B6 and quercetin. |
Estimated with the Hardy-Weinberg principle from the variant's population frequency, not measured directly.
How to get and read your raw DNA file
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