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Interconverts serine and glycine with THF. Key for one-carbon metabolism.
| Genotype | Impact | What it means |
|---|---|---|
| CC (Normal) | Normal | Normal one-carbon metabolism - folate is distributed efficiently between DNA synthesis and methylation. Maintain folate-rich foods. |
| CT (Carrier) | Low impact | Slightly altered folate flux. Ensure adequate natural folate (leafy greens, legumes) and B12, especially alongside MTHFR variants. |
| TT (Variant) | Moderate | May shift folate use and affect methylation. Prioritise natural folate and B12; methylfolate can help if combined with MTHFR variants. |
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