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Master regulator of fat storage and insulin sensitivity
Controls adipocyte differentiation and glucose homeostasis
| Genotype | Impact | What it means |
|---|---|---|
| CC (Normal) | Normal | Pro Pro higher fat storage efficiency |
| CG (Carrier) | Low impact | Pro12Ala carrier, favourable variant : improved insulin sensitivity and reduced type 2 diabetes risk. Diet rich in monounsaturated fats (olive oil, nuts, avocado) amplifies the protective effect. |
| GG (Variant) | Moderate | Ala Ala lower T2DM risk less efficient fat storage |
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