Bone & Joint Health

COL1A1 Collagen Type I Alpha 1

Bone and tendon structure. Injury risk.

Chromosome
17
Variants read
1
Foods
0
Fig. 1Position of COL1A1 on chromosome 17 approximate, banding stylised
COL1A1 · rs1800012
0 Mb · p armcentromereq arm · 81 Mb
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Analyzed variants (SNPs)

How to read this: each row is one possible genotype, the two DNA letters you carry at this position, one inherited from each parent. "Normal" matches the more common version; "Carrier" (heterozygous) means you have one copy of each version, usually a partial effect; "Variant" (homozygous) means both copies carry the less common version, usually the strongest effect. The estimated frequency below is calculated from the variant's frequency in the general population (Hardy-Weinberg principle) — it is a population estimate, not a measurement of our own customers.

rs1800012 COL1A1 Sp1 Population frequency: 18.0% Chr. 17 : 50,200,388
Genotype Impact Est. frequency What it means
GGNormal Normal ~67% G/G: normal type I collagen; standard bone and ligament strength.
GTCarrier Low impact ~30% G/T: slightly altered type I collagen ratio; small increase in ligament-injury susceptibility. Load progression and strength work matter.
TTVariant Moderate ~3% T/T: altered type I collagen assembly, associated with lower bone density and a higher risk of cruciate-ligament and stress injuries. Strength training, calcium and vitamin D are protective.

Estimated with the Hardy-Weinberg principle from the variant's population frequency, not measured directly.

Related reading

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