Indice completo delle varianti genetiche

Fast-twitch muscle fiber protein. R577X sprint gene.

Converts pyridoxal phosphate to pyridoxal for cellular uptake.

Essential partner of cubilin for B12 absorption.

Metabolizes pyridoxal to 4-pyridoxic acid.

Secondary pathway for carotenoid cleavage.

Supports neuron survival and growth. Val66Met affects memory.

Oxidizes choline to betaine aldehyde.

Tendon and ligament injury risk.

Receptor for intrinsic factor-B12 complex in ileum.

Inactivates vitamin D metabolites. Regulates vitamin D levels.

Kidney enzyme converting 25OHD to active 1,25OH2D.

Metabolizes vitamin E and vitamin K.

Reduces dihydrofolate to tetrahydrofolate. Crucial for folate cycle.

Converts T4 to active T3 in tissues.

Intestinal enzyme for dietary folate absorption.

Vitamin K-dependent carboxylation of clotting factors.

Intrinsic factor production for B12 absorption.

Esterifies retinol for storage in liver.

Intracellular processing of B12.

Enzima chiave nel metabolismo dei folati e nel ciclo di metilazione

Mantiene l'enzima MTR in stato attivo

Associated with vitamin D levels.

Phosphorylates vitamin B6 vitamers to active forms.

Sintetizza la fosfatidilcolina de novo; importante per la salute del fegato e lo sviluppo delle membrane fetali

Sleep timing

Converts pyridoxine/pyridoxamine to active pyridoxal-5-phosphate.

Major transport protein for retinol in blood.

Interconverts serine and glycine with THF. Key for one-carbon metabolism.

Reduced folate carrier for cellular folate uptake.

Trasportatore intestinale di vitamina C

SVCT2 - vitamin C transporter in various tissues.

Cellular receptor for retinol uptake from RBP4.

Haptocorrin - binds B12 in saliva and stomach.

Liver protein regulating alpha-tocopherol blood levels.

Essential for DNA synthesis. Target of folate-related metabolism.

Recettore nucleare che media gli effetti della vitamina D

Recycles vitamin K for clotting factor activation.

Intestinal copper absorption and transport.

Copper excretion in liver. Wilson disease gene.

Converte il beta-carotene in vitamina A

Recettore sensore del calcio nel sangue; regola la secrezione di paratormone e l omeostasi del calcio

Magnesium transport in kidney.

Copper transport protein and ferroxidase.

Enzyme that activates vitamin D in the liver

Provides precursor for vitamin D synthesis in skin.

Selenium-dependent thyroid hormone activation.

Iron storage with ferroxidase activity.

Iron storage protein component.

Influenza l'assorbimento della B12 nell'intestino

Principale proteina di trasporto per la vitamina D nel sangue

Riduce gli idroperossidi tramite il glutatione; protezione dal danno ossidativo attraverso il selenio

Lipid-specific selenoprotein antioxidant.

Master regulator of iron absorption.

Zinc binding and homeostasis protein.

Major metallothionein for zinc homeostasis.

Rigenera la metionina dall'omocisteina utilizzando la vitamina B12

Major selenium transport protein in blood.

Intestinal iron absorption transporter.

Major intestinal zinc absorption transporter.

Exports iron from cells to blood.

Active iodide transport into thyroid.

Iron uptake in liver. Regulates hepcidin.

Precursor for thyroid hormone synthesis.

Thyroid hormone synthesis enzyme.

Primary intestinal magnesium absorption channel.

Ubiquitous magnesium channel.

Epithelial calcium channel for absorption.

Intestinal calcium absorption channel.

Fructose metabolism enzyme. Hereditary fructose intolerance.

Diamine oxidase - degrades histamine in gut.

Converte l omocisteina in cistationina; primo passo della via di transolforazione

Immune regulation gene linked to celiac disease.

Regola l'assorbimento del ferro nell'intestino

Inattiva l istamina tramite N-metilazione intracellulare; complementare alla DAO extracellulare

Enzyme that digests lactose (milk sugar)

Regola l'espressione del gene della lattasi (tolleranza al lattosio)

Fructose transporter in intestine.

Trasporta lo zinco nei granuli secretori delle cellule beta pancreatiche

Oxidizes sulfite to sulfate. Essential detoxification.

Main iron transport protein in blood.

Regulates hepcidin. Matriptase-2.

P-glycoprotein efflux pump. Drug transport.

Converts hydrogen peroxide to water.

Metabolizes polycyclic aromatic hydrocarbons.

Drug metabolism. Proton pump inhibitors.

Major drug metabolizing enzyme. Warfarin metabolism.

Metabolizes 25 percent of all drugs. Highly polymorphic.

Metabolizes 50 percent of all drugs. Major CYP enzyme.

Additional drug metabolism pathway.

Principale enzima per la degradazione dell istamina nell intestino; influenza l intolleranza all istamina e le reazioni ...

Detoxification enzyme important for antioxidant defense

Detoxification enzyme important for toxin elimination

Celiac disease risk

Celiac disease risk

HLA-DQ2 DQ8 component for celiac disease risk.

HLA-DQ2 DQ8 component for celiac disease risk.

Acetylation of drugs and carcinogens.

Disintossica i chinoni e protegge dallo stress ossidativo

Cilantro taste

Cytoplasmic antioxidant enzyme.

Neutralizza i radicali superossido nei mitocondri; protezione dallo stress ossidativo

Sulfation of phenols and estrogens.

Bitter taste perception

Bilirubin conjugation. Gilbert syndrome.

HDL component

Triglyceride metabolism

Principale regolatore del ritmo circadiano; influenza il ciclo sonno-veglia, il metabolismo e la secrezione ormonale

Degrada le catecolamine (dopamina, adrenalina, noradrenalina); influenza umore, cognizione e risposta allo stress

Dopamine reuptake. ADHD medication target.

Linked to novelty seeking and ADHD.

Metabolismo degli acidi grassi omega-3 e omega-6

Enzyme involved in omega fatty acid metabolism

GABA receptor affecting anxiety and alcohol response.

Synthesizes GABA from glutamate.

Major serotonin receptor. Affects mood and appetite.

Insulin signaling cascade.

HDL metabolism

Degrades serotonin dopamine norepinephrine. Warrior gene.

Primarily degrades dopamine and phenylethylamine.

Core circadian rhythm gene.

Antioxidant enzyme

Principale regolatore della differenziazione delle cellule adipose e della sensibilita all'insulina

Serotonin reuptake. SSRI target. Short Long alleles.

Piu forte fattore di rischio genetico per il diabete di tipo 2

Rate-limiting enzyme in dopamine synthesis.

Peripheral serotonin synthesis.

Brain serotonin synthesis.

Leukotriene synthesis. Inflammation pathway.

Estrogen metabolism. Affects detox capacity.

Enzima di detossificazione di fase II che coniuga il glutatione alle tossine

Th1 cytokine. Immune activation.

Anti-inflammatory cytokine.

Major pro-inflammatory cytokine.

Th2 cytokine. Allergies and atopy.

Enzima di fase II che metabolizza le ammine aromatiche e l'isoniazide

Master inflammatory transcription factor.

Principale citochina pro-infiammatoria; regola l infiammazione sistemica e la difesa immunitaria

Sulfonylurea receptor. Insulin secretion.

Salivary amylase. Starch digestion. Copy number varies.

Inflammatory marker. Cardiovascular risk.

Glucose sensor in pancreas and liver. MODY2.

Transcription factor for insulin secretion. MODY3.

Glucose metabolism regulator. MODY1.

Regola l infiammazione acuta e le risposte immunitarie; influenza la rigenerazione muscolare e la sensibilità all insuli...

Insulin signaling in liver and beta cells.

Pancreatic beta cell potassium channel.

Master regulator of mitochondrial biogenesis.

Glucose transporter in liver and pancreas.

Insulin-responsive glucose transporter.

Primo passo nel metabolismo dell'alcol

Additional alcohol dehydrogenase isoform.

Stomach alcohol metabolism.

Caffeine blocks this receptor. Affects sensitivity.

Induces CYP1A2 expression.

Converte l'acetaldeide in acetato

Enzima principale per il metabolismo della caffeina

Alternative alcohol metabolism pathway.

Brown fat thermogenesis receptor.

Hunger hormone.

Satiety hormone from fat tissue.

Potent appetite stimulant.

Precursor for satiety signals alpha-MSH.

Strongly associated with BMI.

Brown fat thermogenesis protein.

Energy expenditure regulation.

Muscle energy expenditure.

Reverse cholesterol transport. HDL formation.

Converte l'angiotensina I in II; regola la pressione arteriosa

Salt-sensitive blood pressure gene.

Insulin sensitivity and fat metabolism hormone.

Receptor involved in bronchodilation and fat metabolism

Precursor in blood pressure regulation.

Inhibits LPL. Regulates triglycerides.

Inhibits LPL in fasting state.

Main protein of HDL. Cardioprotective.

Main protein of LDL. Familial hypercholesterolemia gene.

Inhibits lipoprotein lipase. Affects triglycerides.

Metabolismo dei lipidi e salute cardiovascolare

Major dopamine receptor. Affects reward sensitivity.

Sintetizza acidi grassi omega-3 a catena molto lunga (EPA a DHA); marcatore di metilazione del DNA per l invecchiamento ...

Coinvolto nella sintesi di acidi grassi a catena lunga da precursori C18 e C20; influenza l equilibrio omega-3 e omega-6

Influenza la regolazione dell'appetito e l'accumulo di grasso

Rate-limiting enzyme in cholesterol synthesis. Statin target.

Clears LDL from blood. Familial hypercholesterolemia.

Hypothalamic leptin signaling.

Breaks down triglycerides in lipoproteins.

Central appetite regulation. Satiety signaling.

Produces NO for vasodilation.

Intestinal cholesterol absorption. Ezetimibe target.

Regola la degradazione del recettore LDL e i livelli di LDL-colesterolo

I D polymorphism affects endurance vs power.

Energy metabolism during exercise.

Trasferisce gli esteri del colesterolo tra particelle HDL e LDL

Bone and tendon structure. Injury risk.

Red blood cell production for oxygen capacity.

Joint and cartilage development. Injury risk.

Response to low oxygen. Altitude adaptation.

Lactate transport during exercise.

Muscle growth inhibitor. Less equals more muscle.

Vasodilation and blood flow during exercise.

Fat oxidation during exercise.

Endurance training adaptation. Mitochondrial biogenesis.

Angiogenesis for endurance adaptation.

Converte l omocisteina in metionina; via di metilazione alternativa indipendente dalla B12

Main transport protein for B12 delivery to tissues.