Indice completo delle varianti genetiche

Fast-twitch muscle fiber protein. R577X sprint gene.

Energy metabolism during exercise.

Red blood cell production for oxygen capacity.

Response to low oxygen. Altitude adaptation.

Lactate transport during exercise.

Muscle growth inhibitor. Less equals more muscle.

Converts pyridoxal phosphate to pyridoxal for cellular uptake.

Essential partner of cubilin for B12 absorption.

Metabolizes pyridoxal to 4-pyridoxic acid.

Converte il beta-carotene in vitamina A

Secondary pathway for carotenoid cleavage.

Receptor for intrinsic factor-B12 complex in ileum.

Inactivates vitamin D metabolites. Regulates vitamin D levels.

Kidney enzyme converting 25OHD to active 1,25OH2D.

Enzyme that activates vitamin D in the liver

Metabolizes vitamin E and vitamin K.

Provides precursor for vitamin D synthesis in skin.

Reduces dihydrofolate to tetrahydrofolate. Crucial for folate cycle.

Intestinal enzyme for dietary folate absorption.

Influenza l'assorbimento della B12 nell'intestino

Principale proteina di trasporto per la vitamina D nel sangue

Vitamin K-dependent carboxylation of clotting factors.

Intrinsic factor production for B12 absorption.

Esterifies retinol for storage in liver.

Intracellular processing of B12.

Enzima chiave nel metabolismo dei folati e nel ciclo di metilazione

Rigenera la metionina dall'omocisteina utilizzando la vitamina B12

Mantiene l'enzima MTR in stato attivo

Associated with vitamin D levels.

Phosphorylates vitamin B6 vitamers to active forms.

Converts pyridoxine/pyridoxamine to active pyridoxal-5-phosphate.

Major transport protein for retinol in blood.

Reduced folate carrier for cellular folate uptake.

Trasportatore intestinale di vitamina C

SVCT2 - vitamin C transporter in various tissues.

Cellular receptor for retinol uptake from RBP4.

Haptocorrin - binds B12 in saliva and stomach.

Main transport protein for B12 delivery to tissues.

Liver protein regulating alpha-tocopherol blood levels.

Essential for DNA synthesis. Target of folate-related metabolism.

Recettore nucleare che media gli effetti della vitamina D

Recycles vitamin K for clotting factor activation.

Intestinal copper absorption and transport.

ATP7B encodes a copper-transporting ATPase that moves excess copper out of liver cells and into bile for excretion. Loss...

Magnesium transport in kidney.

Copper transport protein and ferroxidase.

Selenium-dependent thyroid hormone activation.

Converts T4 to active T3 in tissues.

Iron storage with ferroxidase activity.

Iron storage protein component.

Master regulator of iron absorption.

Regola l'assorbimento del ferro nell'intestino

Zinc binding and homeostasis protein.

Major metallothionein for zinc homeostasis.

Major selenium transport protein in blood.

Intestinal iron absorption transporter.

Trasporta lo zinco nei granuli secretori delle cellule beta pancreatiche

Major intestinal zinc absorption transporter.

Exports iron from cells to blood.

Active iodide transport into thyroid.

Main iron transport protein in blood.

Iron uptake in liver. Regulates hepcidin.

Precursor for thyroid hormone synthesis.

Regulates hepcidin. Matriptase-2.

Thyroid hormone synthesis enzyme.

Primary intestinal magnesium absorption channel.

Ubiquitous magnesium channel.

Epithelial calcium channel for absorption.

Intestinal calcium absorption channel.

Fructose metabolism enzyme. Hereditary fructose intolerance.

Immune regulation gene linked to celiac disease.

Celiac disease risk

Celiac disease risk

HLA-DQ2 DQ8 component for celiac disease risk.

HLA-DQ2 DQ8 component for celiac disease risk.

Enzyme that digests lactose (milk sugar)

Regola l'espressione del gene della lattasi (tolleranza al lattosio)

Cilantro taste

Fructose transporter in intestine.

Oxidizes sulfite to sulfate. Essential detoxification.

Bitter taste perception

Sulfonylurea receptor. Insulin secretion.

Salivary amylase. Starch digestion. Copy number varies.

HDL component

Triglyceride metabolism

Sintetizza acidi grassi omega-3 a catena molto lunga (EPA a DHA); marcatore di metilazione del DNA per l invecchiamento ...

Coinvolto nella sintesi di acidi grassi a catena lunga da precursori C18 e C20; influenza l equilibrio omega-3 e omega-6

Metabolismo degli acidi grassi omega-3 e omega-6

Enzyme involved in omega fatty acid metabolism

Glucose sensor in pancreas and liver. MODY2.

Transcription factor for insulin secretion. MODY3.

Glucose metabolism regulator. MODY1.

Insulin signaling cascade.

Insulin signaling in liver and beta cells.

Pancreatic beta cell potassium channel.

HDL metabolism

PNPLA3 codifica un enzima lipasi che scompone i trigliceridi immagazzinati nelle cellule epatiche. Alcune varianti compr...

Fat oxidation during exercise.

Master regulator of mitochondrial biogenesis.

Endurance training adaptation. Mitochondrial biogenesis.

Glucose transporter in liver and pancreas.

Insulin-responsive glucose transporter.

Piu forte fattore di rischio genetico per il diabete di tipo 2

P-glycoprotein efflux pump. Drug transport.

Metabolizes polycyclic aromatic hydrocarbons.

Estrogen metabolism. Affects detox capacity.

Drug metabolism. Proton pump inhibitors.

Major drug metabolizing enzyme. Warfarin metabolism.

Metabolizes 25 percent of all drugs. Highly polymorphic.

Metabolizes 50 percent of all drugs. Major CYP enzyme.

Additional drug metabolism pathway.

Detoxification enzyme important for antioxidant defense

Enzima di detossificazione di fase II che coniuga il glutatione alle tossine

Detoxification enzyme important for toxin elimination

Acetylation of drugs and carcinogens.

Enzima di fase II che metabolizza le ammine aromatiche e l'isoniazide

Disintossica i chinoni e protegge dallo stress ossidativo

Sulfation of phenols and estrogens.

Bilirubin conjugation. Gilbert syndrome.

Leukotriene synthesis. Inflammation pathway.

Inflammatory marker. Cardiovascular risk.

Th1 cytokine. Immune activation.

Anti-inflammatory cytokine.

Major pro-inflammatory cytokine.

Th2 cytokine. Allergies and atopy.

Regola l infiammazione acuta e le risposte immunitarie; influenza la rigenerazione muscolare e la sensibilità all insuli...

Master inflammatory transcription factor.

Principale citochina pro-infiammatoria; regola l infiammazione sistemica e la difesa immunitaria

Converts hydrogen peroxide to water.

Riduce gli idroperossidi tramite il glutatione; protezione dal danno ossidativo attraverso il selenio

Lipid-specific selenoprotein antioxidant.

Cytoplasmic antioxidant enzyme.

Neutralizza i radicali superossido nei mitocondri; protezione dallo stress ossidativo

Caffeine blocks this receptor. Affects sensitivity.

Induces CYP1A2 expression.

Enzima principale per il metabolismo della caffeina

Primo passo nel metabolismo dell'alcol

Additional alcohol dehydrogenase isoform.

Stomach alcohol metabolism.

Converte l'acetaldeide in acetato

Alternative alcohol metabolism pathway.

Insulin sensitivity and fat metabolism hormone.

Receptor involved in bronchodilation and fat metabolism

Brown fat thermogenesis receptor.

Influenza la regolazione dell'appetito e l'accumulo di grasso

Hunger hormone.

Satiety hormone from fat tissue.

Hypothalamic leptin signaling.

Central appetite regulation. Satiety signaling.

Potent appetite stimulant.

Precursor for satiety signals alpha-MSH.

Principale regolatore della differenziazione delle cellule adipose e della sensibilita all'insulina

Strongly associated with BMI.

Brown fat thermogenesis protein.

Energy expenditure regulation.

Muscle energy expenditure.

Reverse cholesterol transport. HDL formation.

Converte l'angiotensina I in II; regola la pressione arteriosa

I D polymorphism affects endurance vs power.

Salt-sensitive blood pressure gene.

Precursor in blood pressure regulation.

Inhibits LPL. Regulates triglycerides.

Inhibits LPL in fasting state.

Main protein of HDL. Cardioprotective.

Main protein of LDL. Familial hypercholesterolemia gene.

Inhibits lipoprotein lipase. Affects triglycerides.

Metabolismo dei lipidi e salute cardiovascolare

Trasferisce gli esteri del colesterolo tra particelle HDL e LDL

Rate-limiting enzyme in cholesterol synthesis. Statin target.

Clears LDL from blood. Familial hypercholesterolemia.

Breaks down triglycerides in lipoproteins.

Produces NO for vasodilation.

Vasodilation and blood flow during exercise.

Intestinal cholesterol absorption. Ezetimibe target.

Regola la degradazione del recettore LDL e i livelli di LDL-colesterolo

Antioxidant enzyme

Angiogenesis for endurance adaptation.

Recettore sensore del calcio nel sangue; regola la secrezione di paratormone e l omeostasi del calcio

Bone and tendon structure. Injury risk.

Tendon and ligament injury risk.

Joint and cartilage development. Injury risk.

Converte l omocisteina in metionina; via di metilazione alternativa indipendente dalla B12

Converte l omocisteina in cistationina; primo passo della via di transolforazione

Oxidizes choline to betaine aldehyde.

Sintetizza la fosfatidilcolina de novo; importante per la salute del fegato e lo sviluppo delle membrane fetali

Interconverts serine and glycine with THF. Key for one-carbon metabolism.

Principale enzima per la degradazione dell istamina nell intestino; influenza l intolleranza all istamina e le reazioni ...

Inattiva l istamina tramite N-metilazione intracellulare; complementare alla DAO extracellulare

Principale regolatore del ritmo circadiano; influenza il ciclo sonno-veglia, il metabolismo e la secrezione ormonale

Core circadian rhythm gene.

Sleep timing

Supports neuron survival and growth. Val66Met affects memory.

Degrada le catecolamine (dopamina, adrenalina, noradrenalina); influenza umore, cognizione e risposta allo stress

Dopamine reuptake. ADHD medication target.

Major dopamine receptor. Affects reward sensitivity.

Linked to novelty seeking and ADHD.

GABA receptor affecting anxiety and alcohol response.

Synthesizes GABA from glutamate.

Major serotonin receptor. Affects mood and appetite.

Degrada serotonina, dopamina e noradrenalina. Il «gene del guerriero».

Primarily degrades dopamine and phenylethylamine.

Serotonin reuptake. SSRI target. Short Long alleles.

Rate-limiting enzyme in dopamine synthesis.

Peripheral serotonin synthesis.

Brain serotonin synthesis.