ACTN3
Alpha-Actinin-3
Fast-twitch muscle fiber protein. R577X sprint gene.
Idioma
Cada gen y SNP analizado en tu informe FuelYourDNA, organizado por categoría de salud.
Fast-twitch muscle fiber protein. R577X sprint gene.
Energy metabolism during exercise.
Red blood cell production for oxygen capacity.
Response to low oxygen. Altitude adaptation.
Lactate transport during exercise.
Muscle growth inhibitor. Less equals more muscle.
Converts pyridoxal phosphate to pyridoxal for cellular uptake.
Essential partner of cubilin for B12 absorption.
Metabolizes pyridoxal to 4-pyridoxic acid.
Convierte el beta-caroteno en vitamina A
Secondary pathway for carotenoid cleavage.
Receptor for intrinsic factor-B12 complex in ileum.
Inactivates vitamin D metabolites. Regulates vitamin D levels.
Kidney enzyme converting 25OHD to active 1,25OH2D.
Enzyme that activates vitamin D in the liver
Metabolizes vitamin E and vitamin K.
Provides precursor for vitamin D synthesis in skin.
Reduces dihydrofolate to tetrahydrofolate. Crucial for folate cycle.
Intestinal enzyme for dietary folate absorption.
Influye en la absorcion de B12 en el intestino
Principal proteina transportadora de vitamina D en sangre
Vitamin K-dependent carboxylation of clotting factors.
Intrinsic factor production for B12 absorption.
Esterifies retinol for storage in liver.
Intracellular processing of B12.
Enzima clave en el metabolismo del folato y el ciclo de metilacion
Regenera metionina a partir de homocisteina utilizando vitamina B12
Mantiene la enzima MTR en estado activo
Associated with vitamin D levels.
Phosphorylates vitamin B6 vitamers to active forms.
Converts pyridoxine/pyridoxamine to active pyridoxal-5-phosphate.
Major transport protein for retinol in blood.
Reduced folate carrier for cellular folate uptake.
Transportador intestinal de vitamina C
SVCT2 - vitamin C transporter in various tissues.
Cellular receptor for retinol uptake from RBP4.
Haptocorrin - binds B12 in saliva and stomach.
Main transport protein for B12 delivery to tissues.
Liver protein regulating alpha-tocopherol blood levels.
Essential for DNA synthesis. Target of folate-related metabolism.
Receptor nuclear que media los efectos de la vitamina D
Recycles vitamin K for clotting factor activation.
Intestinal copper absorption and transport.
ATP7B encodes a copper-transporting ATPase that moves excess copper out of liver cells and into bile for excretion. Loss...
Magnesium transport in kidney.
Copper transport protein and ferroxidase.
Selenium-dependent thyroid hormone activation.
Converts T4 to active T3 in tissues.
Iron storage with ferroxidase activity.
Iron storage protein component.
Master regulator of iron absorption.
Regula la absorcion de hierro en el intestino
Zinc binding and homeostasis protein.
Major metallothionein for zinc homeostasis.
Major selenium transport protein in blood.
Intestinal iron absorption transporter.
Transporta zinc a los granulos secretores de las celulas beta pancreaticas
Major intestinal zinc absorption transporter.
Exports iron from cells to blood.
Active iodide transport into thyroid.
Main iron transport protein in blood.
Iron uptake in liver. Regulates hepcidin.
Precursor for thyroid hormone synthesis.
Regulates hepcidin. Matriptase-2.
Thyroid hormone synthesis enzyme.
Primary intestinal magnesium absorption channel.
Ubiquitous magnesium channel.
Epithelial calcium channel for absorption.
Intestinal calcium absorption channel.
Fructose metabolism enzyme. Hereditary fructose intolerance.
Immune regulation gene linked to celiac disease.
Celiac disease risk
Celiac disease risk
HLA-DQ2 DQ8 component for celiac disease risk.
HLA-DQ2 DQ8 component for celiac disease risk.
Enzyme that digests lactose (milk sugar)
Regula la expresion del gen de la lactasa (tolerancia a la lactosa)
Cilantro taste
Fructose transporter in intestine.
Oxidizes sulfite to sulfate. Essential detoxification.
Bitter taste perception
Sulfonylurea receptor. Insulin secretion.
Salivary amylase. Starch digestion. Copy number varies.
HDL component
Triglyceride metabolism
Sintetiza ácidos grasos omega-3 de cadena muy larga (EPA a DHA); marcador de metilación del ADN para el envejecimiento b...
Involucrado en la síntesis de ácidos grasos de cadena larga a partir de precursores C18 y C20; influye en el equilibrio ...
Metabolismo de acidos grasos omega-3 y omega-6
Enzyme involved in omega fatty acid metabolism
Glucose sensor in pancreas and liver. MODY2.
Transcription factor for insulin secretion. MODY3.
Glucose metabolism regulator. MODY1.
Insulin signaling cascade.
Insulin signaling in liver and beta cells.
Pancreatic beta cell potassium channel.
HDL metabolism
PNPLA3 codifica una enzima lipasa que descompone los triglicéridos almacenados en las células hepáticas. Ciertas variant...
Fat oxidation during exercise.
Master regulator of mitochondrial biogenesis.
Endurance training adaptation. Mitochondrial biogenesis.
Glucose transporter in liver and pancreas.
Insulin-responsive glucose transporter.
Principal factor de riesgo genetico para la diabetes tipo 2
P-glycoprotein efflux pump. Drug transport.
Metabolizes polycyclic aromatic hydrocarbons.
Estrogen metabolism. Affects detox capacity.
Drug metabolism. Proton pump inhibitors.
Major drug metabolizing enzyme. Warfarin metabolism.
Metabolizes 25 percent of all drugs. Highly polymorphic.
Metabolizes 50 percent of all drugs. Major CYP enzyme.
Additional drug metabolism pathway.
Detoxification enzyme important for antioxidant defense
Enzima de detoxificacion de fase II que conjuga glutation a toxinas
Detoxification enzyme important for toxin elimination
Acetylation of drugs and carcinogens.
Enzima de fase II que metaboliza aminas aromaticas e isoniazida
Desintoxica quinonas y protege contra el estres oxidativo
Sulfation of phenols and estrogens.
Bilirubin conjugation. Gilbert syndrome.
Leukotriene synthesis. Inflammation pathway.
Inflammatory marker. Cardiovascular risk.
Th1 cytokine. Immune activation.
Anti-inflammatory cytokine.
Major pro-inflammatory cytokine.
Th2 cytokine. Allergies and atopy.
Regula la inflamación aguda y las respuestas inmunes; influye en la regeneración muscular y la sensibilidad a la insulin...
Master inflammatory transcription factor.
Principal citocina proinflamatoria; regula la inflamación sistémica y la defensa inmune
Converts hydrogen peroxide to water.
Reduce hidroperóxidos con glutatión; protección contra el daño oxidativo mediante selenio
Lipid-specific selenoprotein antioxidant.
Cytoplasmic antioxidant enzyme.
Neutraliza radicales superóxido en las mitocondrias; protección contra el estrés oxidativo
Primer paso del metabolismo del alcohol
Additional alcohol dehydrogenase isoform.
Stomach alcohol metabolism.
Convierte el acetaldehido en acetato
Alternative alcohol metabolism pathway.
Insulin sensitivity and fat metabolism hormone.
Receptor involved in bronchodilation and fat metabolism
Brown fat thermogenesis receptor.
Influye en la regulacion del apetito y el almacenamiento de grasa
Hunger hormone.
Satiety hormone from fat tissue.
Hypothalamic leptin signaling.
Central appetite regulation. Satiety signaling.
Potent appetite stimulant.
Precursor for satiety signals alpha-MSH.
Regulador principal de la diferenciacion de celulas adiposas y la sensibilidad a la insulina
Strongly associated with BMI.
Brown fat thermogenesis protein.
Energy expenditure regulation.
Muscle energy expenditure.
Reverse cholesterol transport. HDL formation.
Convierte angiotensina I en II; regula la presion arterial
I D polymorphism affects endurance vs power.
Salt-sensitive blood pressure gene.
Precursor in blood pressure regulation.
Inhibits LPL. Regulates triglycerides.
Inhibits LPL in fasting state.
Main protein of HDL. Cardioprotective.
Main protein of LDL. Familial hypercholesterolemia gene.
Inhibits lipoprotein lipase. Affects triglycerides.
Metabolismo de lipidos y salud cardiovascular
Transfiere esteres de colesterol entre particulas HDL y LDL
Rate-limiting enzyme in cholesterol synthesis. Statin target.
Clears LDL from blood. Familial hypercholesterolemia.
Breaks down triglycerides in lipoproteins.
Produces NO for vasodilation.
Vasodilation and blood flow during exercise.
Intestinal cholesterol absorption. Ezetimibe target.
Regula la degradacion del receptor LDL y los niveles de LDL-colesterol
Antioxidant enzyme
Angiogenesis for endurance adaptation.
Receptor sensor de calcio en sangre; regula la secreción de parathormona y la homeostasis del calcio
Bone and tendon structure. Injury risk.
Tendon and ligament injury risk.
Joint and cartilage development. Injury risk.
Convierte homocisteína en metionina; vía alternativa de metilación independiente de B12
Convierte homocisteína en cistationina; primer paso de la vía de transulfuración
Oxidizes choline to betaine aldehyde.
Sintetiza fosfatidilcolina de novo; importante para la salud hepática y el desarrollo de membranas fetales
Interconverts serine and glycine with THF. Key for one-carbon metabolism.
Supports neuron survival and growth. Val66Met affects memory.
Degrada catecolaminas (dopamina, adrenalina, noradrenalina); influye en el estado de ánimo, la cognición y la respuesta ...
Dopamine reuptake. ADHD medication target.
Major dopamine receptor. Affects reward sensitivity.
Linked to novelty seeking and ADHD.
GABA receptor affecting anxiety and alcohol response.
Synthesizes GABA from glutamate.
Major serotonin receptor. Affects mood and appetite.
Degrada la serotonina, la dopamina y la noradrenalina. El «gen guerrero».
Primarily degrades dopamine and phenylethylamine.
Serotonin reuptake. SSRI target. Short Long alleles.
Rate-limiting enzyme in dopamine synthesis.
Peripheral serotonin synthesis.
Brain serotonin synthesis.
Cargue su archivo 23andMe o AncestryDNA.
Obtener mi informe de ADN →