Complete SNP & Gene Variant Index

Fast-twitch muscle fiber protein. R577X sprint gene.

Converts pyridoxal phosphate to pyridoxal for cellular uptake.

Essential partner of cubilin for B12 absorption.

Metabolizes pyridoxal to 4-pyridoxic acid.

Secondary pathway for carotenoid cleavage.

Supports neuron survival and growth. Val66Met affects memory.

Oxidizes choline to betaine aldehyde.

Tendon and ligament injury risk.

Receptor for intrinsic factor-B12 complex in ileum.

Inactivates vitamin D metabolites. Regulates vitamin D levels.

Kidney enzyme converting 25OHD to active 1,25OH2D.

Metabolizes vitamin E and vitamin K.

Reduces dihydrofolate to tetrahydrofolate. Crucial for folate cycle.

Converts T4 to active T3 in tissues.

Intestinal enzyme for dietary folate absorption.

Vitamin K-dependent carboxylation of clotting factors.

Intrinsic factor production for B12 absorption.

Esterifies retinol for storage in liver.

Intracellular processing of B12.

Key enzyme in folate metabolism affecting methylation and homocysteine levels

Maintains MTR enzyme in its active state. Essential for B12-dependent reactions.

Associated with vitamin D levels.

Phosphorylates vitamin B6 vitamers to active forms.

Endogenous choline synthesis. Higher needs in women.

Sleep timing

Converts pyridoxine/pyridoxamine to active pyridoxal-5-phosphate.

Major transport protein for retinol in blood.

Interconverts serine and glycine with THF. Key for one-carbon metabolism.

Reduced folate carrier for cellular folate uptake.

SVCT1 - intestinal vitamin C transporter.

SVCT2 - vitamin C transporter in various tissues.

Cellular receptor for retinol uptake from RBP4.

Haptocorrin - binds B12 in saliva and stomach.

Liver protein regulating alpha-tocopherol blood levels.

Essential for DNA synthesis. Target of folate-related metabolism.

Nuclear receptor that mediates vitamin D effects on calcium absorption and bone health

Recycles vitamin K for clotting factor activation.

Intestinal copper absorption and transport.

Copper excretion in liver. Wilson disease gene.

Enzyme that converts beta-carotene to vitamin A

Senses extracellular calcium levels.

Magnesium transport in kidney.

Copper transport protein and ferroxidase.

Enzyme that activates vitamin D in the liver

Provides precursor for vitamin D synthesis in skin.

Selenium-dependent thyroid hormone activation.

Iron storage with ferroxidase activity.

Iron storage protein component.

Secretor status gene. Affects B12 absorption through gut microbiome.

Main carrier protein for vitamin D in blood

Selenium-dependent antioxidant enzyme.

Lipid-specific selenoprotein antioxidant.

Master regulator of iron absorption.

Zinc binding and homeostasis protein.

Major metallothionein for zinc homeostasis.

Regenerates methionine from homocysteine using vitamin B12 as cofactor.

Major selenium transport protein in blood.

Intestinal iron absorption transporter.

Major intestinal zinc absorption transporter.

Exports iron from cells to blood.

Active iodide transport into thyroid.

Iron uptake in liver. Regulates hepcidin.

Precursor for thyroid hormone synthesis.

Thyroid hormone synthesis enzyme.

Primary intestinal magnesium absorption channel.

Ubiquitous magnesium channel.

Epithelial calcium channel for absorption.

Intestinal calcium absorption channel.

Fructose metabolism enzyme. Hereditary fructose intolerance.

Diamine oxidase - degrades histamine in gut.

Homocysteine metabolism and sulfur amino acid processing.

Immune regulation gene linked to celiac disease.

Major regulator of iron absorption. Mutations cause hemochromatosis.

Intracellular histamine degradation.

Enzyme that digests lactose (milk sugar)

Regulates lactase gene expression in adults

Fructose transporter in intestine.

Zinc transporter in pancreatic beta cells.

Oxidizes sulfite to sulfate. Essential detoxification.

Main iron transport protein in blood.

Regulates hepcidin. Matriptase-2.

P-glycoprotein efflux pump. Drug transport.

Converts hydrogen peroxide to water.

Metabolizes polycyclic aromatic hydrocarbons.

Drug metabolism. Proton pump inhibitors.

Major drug metabolizing enzyme. Warfarin metabolism.

Metabolizes 25 percent of all drugs. Highly polymorphic.

Metabolizes 50 percent of all drugs. Major CYP enzyme.

Additional drug metabolism pathway.

Histamine degradation

Detoxification enzyme important for antioxidant defense

Detoxification enzyme important for toxin elimination

Celiac disease risk

Celiac disease risk

HLA-DQ2 DQ8 component for celiac disease risk.

HLA-DQ2 DQ8 component for celiac disease risk.

Acetylation of drugs and carcinogens.

Quinone detoxification. Vitamin K metabolism.

Cilantro taste

Cytoplasmic antioxidant enzyme.

Primary mitochondrial antioxidant enzyme

Sulfation of phenols and estrogens.

Bitter taste perception

Bilirubin conjugation. Gilbert syndrome.

HDL component

Triglyceride metabolism

Master circadian clock gene.

Enzyme that breaks down catecholamines (dopamine, epinephrine)

Dopamine reuptake. ADHD medication target.

Linked to novelty seeking and ADHD.

Enzyme involved in omega fatty acid metabolism

Enzyme involved in omega fatty acid metabolism

GABA receptor affecting anxiety and alcohol response.

Synthesizes GABA from glutamate.

Major serotonin receptor. Affects mood and appetite.

Insulin signaling cascade.

HDL metabolism

Degrades serotonin dopamine norepinephrine. Warrior gene.

Primarily degrades dopamine and phenylethylamine.

Core circadian rhythm gene.

Antioxidant enzyme

Master regulator of fat storage and insulin sensitivity

Serotonin reuptake. SSRI target. Short Long alleles.

Gene strongly associated with type 2 diabetes risk

Rate-limiting enzyme in dopamine synthesis.

Peripheral serotonin synthesis.

Brain serotonin synthesis.

Leukotriene synthesis. Inflammation pathway.

Estrogen metabolism. Affects detox capacity.

Lung and brain detoxification.

Th1 cytokine. Immune activation.

Anti-inflammatory cytokine.

Major pro-inflammatory cytokine.

Th2 cytokine. Allergies and atopy.

Major drug acetylation enzyme. Slow Fast acetylators.

Master inflammatory transcription factor.

Key inflammatory cytokine

Sulfonylurea receptor. Insulin secretion.

Salivary amylase. Starch digestion. Copy number varies.

Inflammatory marker. Cardiovascular risk.

Glucose sensor in pancreas and liver. MODY2.

Transcription factor for insulin secretion. MODY3.

Glucose metabolism regulator. MODY1.

Pro-inflammatory cytokine involved in immune response

Insulin signaling in liver and beta cells.

Pancreatic beta cell potassium channel.

Master regulator of mitochondrial biogenesis.

Glucose transporter in liver and pancreas.

Insulin-responsive glucose transporter.

First step of alcohol metabolism - converts ethanol to acetaldehyde.

Additional alcohol dehydrogenase isoform.

Stomach alcohol metabolism.

Caffeine blocks this receptor. Affects sensitivity.

Induces CYP1A2 expression.

Enzyme that metabolizes acetaldehyde from alcohol

Liver enzyme responsible for caffeine metabolism

Alternative alcohol metabolism pathway.

Brown fat thermogenesis receptor.

Hunger hormone.

Satiety hormone from fat tissue.

Potent appetite stimulant.

Precursor for satiety signals alpha-MSH.

Strongly associated with BMI.

Brown fat thermogenesis protein.

Energy expenditure regulation.

Muscle energy expenditure.

Reverse cholesterol transport. HDL formation.

Enzyme involved in blood pressure regulation

Salt-sensitive blood pressure gene.

Insulin sensitivity and fat metabolism hormone.

Receptor involved in bronchodilation and fat metabolism

Precursor in blood pressure regulation.

Inhibits LPL. Regulates triglycerides.

Inhibits LPL in fasting state.

Main protein of HDL. Cardioprotective.

Main protein of LDL. Familial hypercholesterolemia gene.

Inhibits lipoprotein lipase. Affects triglycerides.

Major apoprotein involved in lipid transport and cardiovascular health

Major dopamine receptor. Affects reward sensitivity.

Elongates fatty acids in omega-3 synthesis.

Elongation step in PUFA metabolism.

Gene strongly associated with obesity risk and appetite regulation

Rate-limiting enzyme in cholesterol synthesis. Statin target.

Clears LDL from blood. Familial hypercholesterolemia.

Hypothalamic leptin signaling.

Breaks down triglycerides in lipoproteins.

Central appetite regulation. Satiety signaling.

Produces NO for vasodilation.

Intestinal cholesterol absorption. Ezetimibe target.

Degrades LDL receptors. Drug target for cholesterol lowering.

I D polymorphism affects endurance vs power.

Energy metabolism during exercise.

Transfers cholesterol between lipoproteins.

Bone and tendon structure. Injury risk.

Red blood cell production for oxygen capacity.

Joint and cartilage development. Injury risk.

Response to low oxygen. Altitude adaptation.

Lactate transport during exercise.

Muscle growth inhibitor. Less equals more muscle.

Vasodilation and blood flow during exercise.

Fat oxidation during exercise.

Endurance training adaptation. Mitochondrial biogenesis.

Angiogenesis for endurance adaptation.

Uses betaine to remethylate homocysteine.

Main transport protein for B12 delivery to tissues.