Vollständiger Gen-Varianten-Index

Fast-twitch muscle fiber protein. R577X sprint gene.

Energy metabolism during exercise.

Red blood cell production for oxygen capacity.

Response to low oxygen. Altitude adaptation.

Lactate transport during exercise.

Muscle growth inhibitor. Less equals more muscle.

Converts pyridoxal phosphate to pyridoxal for cellular uptake.

Essential partner of cubilin for B12 absorption.

Metabolizes pyridoxal to 4-pyridoxic acid.

Wandelt Beta-Carotin in Vitamin A um

Secondary pathway for carotenoid cleavage.

Receptor for intrinsic factor-B12 complex in ileum.

Inactivates vitamin D metabolites. Regulates vitamin D levels.

Kidney enzyme converting 25OHD to active 1,25OH2D.

Enzyme that activates vitamin D in the liver

Metabolizes vitamin E and vitamin K.

Provides precursor for vitamin D synthesis in skin.

Reduces dihydrofolate to tetrahydrofolate. Crucial for folate cycle.

Intestinal enzyme for dietary folate absorption.

Beeinflusst die B12-Aufnahme im Darm

Haupttransportprotein fuer Vitamin D im Blut

Vitamin K-dependent carboxylation of clotting factors.

Intrinsic factor production for B12 absorption.

Esterifies retinol for storage in liver.

Intracellular processing of B12.

Schluesselenzym im Folsaeure-Stoffwechsel und im Methylierungszyklus

Regeneriert Methionin aus Homocystein mithilfe von Vitamin B12

Haelt das MTR-Enzym in aktivem Zustand

Associated with vitamin D levels.

Phosphorylates vitamin B6 vitamers to active forms.

Converts pyridoxine/pyridoxamine to active pyridoxal-5-phosphate.

Major transport protein for retinol in blood.

Reduced folate carrier for cellular folate uptake.

Intestinaler Vitamin-C-Transporter

SVCT2 - vitamin C transporter in various tissues.

Cellular receptor for retinol uptake from RBP4.

Haptocorrin - binds B12 in saliva and stomach.

Main transport protein for B12 delivery to tissues.

Liver protein regulating alpha-tocopherol blood levels.

Essential for DNA synthesis. Target of folate-related metabolism.

Kernrezeptor, der die Wirkungen von Vitamin D vermittelt

Recycles vitamin K for clotting factor activation.

Intestinal copper absorption and transport.

ATP7B kodiert eine kupfertransportierende ATPase, die überschüssiges Kupfer aus Leberzellen in die Galle transportiert, ...

Magnesium transport in kidney.

Copper transport protein and ferroxidase.

Selenium-dependent thyroid hormone activation.

Converts T4 to active T3 in tissues.

Iron storage with ferroxidase activity.

Iron storage protein component.

Master regulator of iron absorption.

Reguliert die Eisenaufnahme im Darm

Zinc binding and homeostasis protein.

Major metallothionein for zinc homeostasis.

Major selenium transport protein in blood.

Intestinal iron absorption transporter.

Transportiert Zink in die sekretorischen Granula der Pankreas-Betazellen

Major intestinal zinc absorption transporter.

Exports iron from cells to blood.

Active iodide transport into thyroid.

Main iron transport protein in blood.

Iron uptake in liver. Regulates hepcidin.

Precursor for thyroid hormone synthesis.

Regulates hepcidin. Matriptase-2.

Thyroid hormone synthesis enzyme.

Primary intestinal magnesium absorption channel.

Ubiquitous magnesium channel.

Epithelial calcium channel for absorption.

Intestinal calcium absorption channel.

Fructose metabolism enzyme. Hereditary fructose intolerance.

Immune regulation gene linked to celiac disease.

Celiac disease risk

Celiac disease risk

HLA-DQ2 DQ8 component for celiac disease risk.

HLA-DQ2 DQ8 component for celiac disease risk.

Enzyme that digests lactose (milk sugar)

Reguliert die Laktase-Genexpression (Laktosetoleranz)

Cilantro taste

Fructose transporter in intestine.

Oxidizes sulfite to sulfate. Essential detoxification.

Bitter taste perception

Sulfonylurea receptor. Insulin secretion.

Salivary amylase. Starch digestion. Copy number varies.

HDL component

Triglyceride metabolism

Synthetisiert sehr langkettige Omega-3-Fettsäuren (EPA zu DHA); DNA-Methylierungsmarker für biologisches Altern

Beteiligt an der Synthese langkettiger Fettsäuren aus C18- und C20-Vorstufen; beeinflusst Omega-3- und Omega-6-Balance

Omega-3- und Omega-6-Fettsaeure-Stoffwechsel

Enzyme involved in omega fatty acid metabolism

Glucose sensor in pancreas and liver. MODY2.

Transcription factor for insulin secretion. MODY3.

Glucose metabolism regulator. MODY1.

Insulin signaling cascade.

Insulin signaling in liver and beta cells.

Pancreatic beta cell potassium channel.

HDL metabolism

PNPLA3 kodiert ein Lipase-Enzym, das in der Leber gespeicherte Triglyceride abbaut. Bestimmte Varianten beeinträchtigen ...

Fat oxidation during exercise.

Master regulator of mitochondrial biogenesis.

Endurance training adaptation. Mitochondrial biogenesis.

Glucose transporter in liver and pancreas.

Insulin-responsive glucose transporter.

Staerkster genetischer Risikofaktor fuer Typ-2-Diabetes

P-glycoprotein efflux pump. Drug transport.

Metabolizes polycyclic aromatic hydrocarbons.

Estrogen metabolism. Affects detox capacity.

Drug metabolism. Proton pump inhibitors.

Major drug metabolizing enzyme. Warfarin metabolism.

Metabolizes 25 percent of all drugs. Highly polymorphic.

Metabolizes 50 percent of all drugs. Major CYP enzyme.

Additional drug metabolism pathway.

Detoxification enzyme important for antioxidant defense

Phase-II-Entgiftungsenzym, das Glutathion an Giftstoffe konjugiert

Detoxification enzyme important for toxin elimination

Acetylation of drugs and carcinogens.

Phase-II-Enzym, das aromatische Amine und Isoniazid metabolisiert

Entgiftet Chinone und schuetzt vor oxidativem Stress

Sulfation of phenols and estrogens.

Bilirubin conjugation. Gilbert syndrome.

Leukotriene synthesis. Inflammation pathway.

Inflammatory marker. Cardiovascular risk.

Th1 cytokine. Immune activation.

Anti-inflammatory cytokine.

Major pro-inflammatory cytokine.

Th2 cytokine. Allergies and atopy.

Reguliert akute Entzündung und Immunreaktionen; beeinflusst Muskelregeneration und Insulinsensitivität

Master inflammatory transcription factor.

Wichtigstes pro-inflammatorisches Zytokin; reguliert systemische Entzündung und Immunabwehr

Converts hydrogen peroxide to water.

Reduziert Hydroperoxide mithilfe von Glutathion; Schutz vor oxidativem Schaden durch Selen

Lipid-specific selenoprotein antioxidant.

Cytoplasmic antioxidant enzyme.

Neutralisiert Superoxid-Radikale in den Mitochondrien; Schutz vor oxidativem Stress

Caffeine blocks this receptor. Affects sensitivity.

Induces CYP1A2 expression.

Wichtigstes Enzym fuer den Koffein-Stoffwechsel

Erster Schritt im Alkohol-Stoffwechsel

Additional alcohol dehydrogenase isoform.

Stomach alcohol metabolism.

Wandelt Acetaldehyd in Acetat um

Alternative alcohol metabolism pathway.

Insulin sensitivity and fat metabolism hormone.

Receptor involved in bronchodilation and fat metabolism

Brown fat thermogenesis receptor.

Beeinflusst die Appetitregulierung und Fettspeicherung

Hunger hormone.

Satiety hormone from fat tissue.

Hypothalamic leptin signaling.

Central appetite regulation. Satiety signaling.

Potent appetite stimulant.

Precursor for satiety signals alpha-MSH.

Hauptregulator der Fettzelldifferenzierung und Insulinsensitivitaet

Strongly associated with BMI.

Brown fat thermogenesis protein.

Energy expenditure regulation.

Muscle energy expenditure.

Reverse cholesterol transport. HDL formation.

Wandelt Angiotensin I in II um; reguliert den Blutdruck

I D polymorphism affects endurance vs power.

Salt-sensitive blood pressure gene.

Precursor in blood pressure regulation.

Inhibits LPL. Regulates triglycerides.

Inhibits LPL in fasting state.

Main protein of HDL. Cardioprotective.

Main protein of LDL. Familial hypercholesterolemia gene.

Inhibits lipoprotein lipase. Affects triglycerides.

Lipid-Stoffwechsel und kardiovaskulaere Gesundheit

Transferiert Cholesterinester zwischen HDL- und LDL-Partikeln

Rate-limiting enzyme in cholesterol synthesis. Statin target.

Clears LDL from blood. Familial hypercholesterolemia.

Breaks down triglycerides in lipoproteins.

Produces NO for vasodilation.

Vasodilation and blood flow during exercise.

Intestinal cholesterol absorption. Ezetimibe target.

Reguliert den Abbau des LDL-Rezeptors und den LDL-Cholesterin-Spiegel

Antioxidant enzyme

Angiogenesis for endurance adaptation.

Sensorprotein für Kalzium im Blut; reguliert Parathormon-Sekretion und Kalzium-Homöostase

Bone and tendon structure. Injury risk.

Tendon and ligament injury risk.

Joint and cartilage development. Injury risk.

Wandelt Homocystein in Methionin um; alternativer Methylierungsweg unabhängig von B12

Wandelt Homocystein in Cystathionin um; erster Schritt des Transsulfurierungswegs

Oxidizes choline to betaine aldehyde.

Synthetisiert Phosphatidylcholin de novo; wichtig für Lebergesundheit und Fetalmembranentwicklung

Interconverts serine and glycine with THF. Key for one-carbon metabolism.

Hauptenzym für den Histaminabbau im Darm; beeinflusst Histaminintoleranz und allergische Reaktionen

Inaktiviert Histamin durch N-Methylierung im Zellinnern; komplementär zur extrazellulären DAO

Hauptregulator des zirkadianen Rhythmus; beeinflusst Schlaf-Wach-Zyklus, Stoffwechsel und Hormonausschüttung

Core circadian rhythm gene.

Sleep timing

Supports neuron survival and growth. Val66Met affects memory.

Baut Catecholamine (Dopamin, Adrenalin, Noradrenalin) ab; beeinflusst Stimmung, Kognition und Stressreaktion

Dopamine reuptake. ADHD medication target.

Major dopamine receptor. Affects reward sensitivity.

Linked to novelty seeking and ADHD.

GABA receptor affecting anxiety and alcohol response.

Synthesizes GABA from glutamate.

Major serotonin receptor. Affects mood and appetite.

Baut Serotonin, Dopamin und Noradrenalin ab. Das „Krieger-Gen“.

Primarily degrades dopamine and phenylethylamine.

Serotonin reuptake. SSRI target. Short Long alleles.

Rate-limiting enzyme in dopamine synthesis.

Peripheral serotonin synthesis.

Brain serotonin synthesis.