Vollständiger Gen-Varianten-Index

Fast-twitch muscle fiber protein. R577X sprint gene.

Converts pyridoxal phosphate to pyridoxal for cellular uptake.

Essential partner of cubilin for B12 absorption.

Metabolizes pyridoxal to 4-pyridoxic acid.

Secondary pathway for carotenoid cleavage.

Supports neuron survival and growth. Val66Met affects memory.

Oxidizes choline to betaine aldehyde.

Tendon and ligament injury risk.

Receptor for intrinsic factor-B12 complex in ileum.

Inactivates vitamin D metabolites. Regulates vitamin D levels.

Kidney enzyme converting 25OHD to active 1,25OH2D.

Metabolizes vitamin E and vitamin K.

Reduces dihydrofolate to tetrahydrofolate. Crucial for folate cycle.

Converts T4 to active T3 in tissues.

Intestinal enzyme for dietary folate absorption.

Vitamin K-dependent carboxylation of clotting factors.

Intrinsic factor production for B12 absorption.

Esterifies retinol for storage in liver.

Intracellular processing of B12.

Schluesselenzym im Folsaeure-Stoffwechsel und im Methylierungszyklus

Haelt das MTR-Enzym in aktivem Zustand

Associated with vitamin D levels.

Phosphorylates vitamin B6 vitamers to active forms.

Synthetisiert Phosphatidylcholin de novo; wichtig für Lebergesundheit und Fetalmembranentwicklung

Sleep timing

Converts pyridoxine/pyridoxamine to active pyridoxal-5-phosphate.

Major transport protein for retinol in blood.

Interconverts serine and glycine with THF. Key for one-carbon metabolism.

Reduced folate carrier for cellular folate uptake.

Intestinaler Vitamin-C-Transporter

SVCT2 - vitamin C transporter in various tissues.

Cellular receptor for retinol uptake from RBP4.

Haptocorrin - binds B12 in saliva and stomach.

Liver protein regulating alpha-tocopherol blood levels.

Essential for DNA synthesis. Target of folate-related metabolism.

Kernrezeptor, der die Wirkungen von Vitamin D vermittelt

Recycles vitamin K for clotting factor activation.

Intestinal copper absorption and transport.

Copper excretion in liver. Wilson disease gene.

Wandelt Beta-Carotin in Vitamin A um

Sensorprotein für Kalzium im Blut; reguliert Parathormon-Sekretion und Kalzium-Homöostase

Magnesium transport in kidney.

Copper transport protein and ferroxidase.

Enzyme that activates vitamin D in the liver

Provides precursor for vitamin D synthesis in skin.

Selenium-dependent thyroid hormone activation.

Iron storage with ferroxidase activity.

Iron storage protein component.

Beeinflusst die B12-Aufnahme im Darm

Haupttransportprotein fuer Vitamin D im Blut

Reduziert Hydroperoxide mithilfe von Glutathion; Schutz vor oxidativem Schaden durch Selen

Lipid-specific selenoprotein antioxidant.

Master regulator of iron absorption.

Zinc binding and homeostasis protein.

Major metallothionein for zinc homeostasis.

Regeneriert Methionin aus Homocystein mithilfe von Vitamin B12

Major selenium transport protein in blood.

Intestinal iron absorption transporter.

Major intestinal zinc absorption transporter.

Exports iron from cells to blood.

Active iodide transport into thyroid.

Iron uptake in liver. Regulates hepcidin.

Precursor for thyroid hormone synthesis.

Thyroid hormone synthesis enzyme.

Primary intestinal magnesium absorption channel.

Ubiquitous magnesium channel.

Epithelial calcium channel for absorption.

Intestinal calcium absorption channel.

Fructose metabolism enzyme. Hereditary fructose intolerance.

Diamine oxidase - degrades histamine in gut.

Wandelt Homocystein in Cystathionin um; erster Schritt des Transsulfurierungswegs

Immune regulation gene linked to celiac disease.

Reguliert die Eisenaufnahme im Darm

Inaktiviert Histamin durch N-Methylierung im Zellinnern; komplementär zur extrazellulären DAO

Enzyme that digests lactose (milk sugar)

Reguliert die Laktase-Genexpression (Laktosetoleranz)

Fructose transporter in intestine.

Transportiert Zink in die sekretorischen Granula der Pankreas-Betazellen

Oxidizes sulfite to sulfate. Essential detoxification.

Main iron transport protein in blood.

Regulates hepcidin. Matriptase-2.

P-glycoprotein efflux pump. Drug transport.

Converts hydrogen peroxide to water.

Metabolizes polycyclic aromatic hydrocarbons.

Drug metabolism. Proton pump inhibitors.

Major drug metabolizing enzyme. Warfarin metabolism.

Metabolizes 25 percent of all drugs. Highly polymorphic.

Metabolizes 50 percent of all drugs. Major CYP enzyme.

Additional drug metabolism pathway.

Hauptenzym für den Histaminabbau im Darm; beeinflusst Histaminintoleranz und allergische Reaktionen

Detoxification enzyme important for antioxidant defense

Detoxification enzyme important for toxin elimination

Celiac disease risk

Celiac disease risk

HLA-DQ2 DQ8 component for celiac disease risk.

HLA-DQ2 DQ8 component for celiac disease risk.

Acetylation of drugs and carcinogens.

Entgiftet Chinone und schuetzt vor oxidativem Stress

Cilantro taste

Cytoplasmic antioxidant enzyme.

Neutralisiert Superoxid-Radikale in den Mitochondrien; Schutz vor oxidativem Stress

Sulfation of phenols and estrogens.

Bitter taste perception

Bilirubin conjugation. Gilbert syndrome.

HDL component

Triglyceride metabolism

Hauptregulator des zirkadianen Rhythmus; beeinflusst Schlaf-Wach-Zyklus, Stoffwechsel und Hormonausschüttung

Baut Catecholamine (Dopamin, Adrenalin, Noradrenalin) ab; beeinflusst Stimmung, Kognition und Stressreaktion

Dopamine reuptake. ADHD medication target.

Linked to novelty seeking and ADHD.

Omega-3- und Omega-6-Fettsaeure-Stoffwechsel

Enzyme involved in omega fatty acid metabolism

GABA receptor affecting anxiety and alcohol response.

Synthesizes GABA from glutamate.

Major serotonin receptor. Affects mood and appetite.

Insulin signaling cascade.

HDL metabolism

Degrades serotonin dopamine norepinephrine. Warrior gene.

Primarily degrades dopamine and phenylethylamine.

Core circadian rhythm gene.

Antioxidant enzyme

Hauptregulator der Fettzelldifferenzierung und Insulinsensitivitaet

Serotonin reuptake. SSRI target. Short Long alleles.

Staerkster genetischer Risikofaktor fuer Typ-2-Diabetes

Rate-limiting enzyme in dopamine synthesis.

Peripheral serotonin synthesis.

Brain serotonin synthesis.

Leukotriene synthesis. Inflammation pathway.

Estrogen metabolism. Affects detox capacity.

Phase-II-Entgiftungsenzym, das Glutathion an Giftstoffe konjugiert

Th1 cytokine. Immune activation.

Anti-inflammatory cytokine.

Major pro-inflammatory cytokine.

Th2 cytokine. Allergies and atopy.

Phase-II-Enzym, das aromatische Amine und Isoniazid metabolisiert

Master inflammatory transcription factor.

Wichtigstes pro-inflammatorisches Zytokin; reguliert systemische Entzündung und Immunabwehr

Sulfonylurea receptor. Insulin secretion.

Salivary amylase. Starch digestion. Copy number varies.

Inflammatory marker. Cardiovascular risk.

Glucose sensor in pancreas and liver. MODY2.

Transcription factor for insulin secretion. MODY3.

Glucose metabolism regulator. MODY1.

Reguliert akute Entzündung und Immunreaktionen; beeinflusst Muskelregeneration und Insulinsensitivität

Insulin signaling in liver and beta cells.

Pancreatic beta cell potassium channel.

Master regulator of mitochondrial biogenesis.

Glucose transporter in liver and pancreas.

Insulin-responsive glucose transporter.

Erster Schritt im Alkohol-Stoffwechsel

Additional alcohol dehydrogenase isoform.

Stomach alcohol metabolism.

Caffeine blocks this receptor. Affects sensitivity.

Induces CYP1A2 expression.

Wandelt Acetaldehyd in Acetat um

Wichtigstes Enzym fuer den Koffein-Stoffwechsel

Alternative alcohol metabolism pathway.

Brown fat thermogenesis receptor.

Hunger hormone.

Satiety hormone from fat tissue.

Potent appetite stimulant.

Precursor for satiety signals alpha-MSH.

Strongly associated with BMI.

Brown fat thermogenesis protein.

Energy expenditure regulation.

Muscle energy expenditure.

Reverse cholesterol transport. HDL formation.

Wandelt Angiotensin I in II um; reguliert den Blutdruck

Salt-sensitive blood pressure gene.

Insulin sensitivity and fat metabolism hormone.

Receptor involved in bronchodilation and fat metabolism

Precursor in blood pressure regulation.

Inhibits LPL. Regulates triglycerides.

Inhibits LPL in fasting state.

Main protein of HDL. Cardioprotective.

Main protein of LDL. Familial hypercholesterolemia gene.

Inhibits lipoprotein lipase. Affects triglycerides.

Lipid-Stoffwechsel und kardiovaskulaere Gesundheit

Major dopamine receptor. Affects reward sensitivity.

Synthetisiert sehr langkettige Omega-3-Fettsäuren (EPA zu DHA); DNA-Methylierungsmarker für biologisches Altern

Beteiligt an der Synthese langkettiger Fettsäuren aus C18- und C20-Vorstufen; beeinflusst Omega-3- und Omega-6-Balance

Beeinflusst die Appetitregulierung und Fettspeicherung

Rate-limiting enzyme in cholesterol synthesis. Statin target.

Clears LDL from blood. Familial hypercholesterolemia.

Hypothalamic leptin signaling.

Breaks down triglycerides in lipoproteins.

Central appetite regulation. Satiety signaling.

Produces NO for vasodilation.

Intestinal cholesterol absorption. Ezetimibe target.

Reguliert den Abbau des LDL-Rezeptors und den LDL-Cholesterin-Spiegel

I D polymorphism affects endurance vs power.

Energy metabolism during exercise.

Transferiert Cholesterinester zwischen HDL- und LDL-Partikeln

Bone and tendon structure. Injury risk.

Red blood cell production for oxygen capacity.

Joint and cartilage development. Injury risk.

Response to low oxygen. Altitude adaptation.

Lactate transport during exercise.

Muscle growth inhibitor. Less equals more muscle.

Vasodilation and blood flow during exercise.

Fat oxidation during exercise.

Endurance training adaptation. Mitochondrial biogenesis.

Angiogenesis for endurance adaptation.

Wandelt Homocystein in Methionin um; alternativer Methylierungsweg unabhängig von B12

Main transport protein for B12 delivery to tissues.