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Inativa histamina por N-metilação intracelular; complementar à DAO extracelular
N-metilação de histamina a N-metilhistamina pelo SAM
| Genótipo | Impacto | O que significa |
|---|---|---|
| CC (Normal) | Normal | Normal HNMT activity - histamine is broken down efficiently inside cells. No special restriction needed. |
| CT (Portador) | Impacto baixo | Moderately reduced HNMT activity - slightly slower histamine clearance. Limit very high-histamine foods (aged cheese, cured meats, wine) if you notice symptoms; ensure adequate vitamin C and B6. |
| TT (Variante) | Moderado | Low HNMT activity - histamine sensitivity likely. Favour a lower-histamine diet (fresh foods, avoid aged/fermented items), support with vitamin C, B6 and quercetin. |
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