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Mantiene la enzima MTR en estado activo
Regenera la metionina sintasa funcional mediante metilacion reductiva
Afecta la capacidad de reciclar la metionina sintasa utilizando B12
| Genotipo | Impacto | Qué significa |
|---|---|---|
| AA (Normal) | Normal | Efficient methionine-synthase recycling - supports B12-dependent methylation. Maintain B12 intake (eggs, fish, meat). |
| AG (Portador) | Impacto bajo | Moderately reduced recycling of B12 in the methylation cycle - slightly higher B12 demand. Ensure regular B12 and folate; consider methylcobalamin if levels are low. |
| GG (Variante) | Moderado | Reduced B12 recycling - higher need for B12 and folate to keep homocysteine in check. Prioritise B12-rich foods or methylcobalamin and monitor B12/homocysteine. |
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