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Microbiome testing is having a moment, and it requires a stool sample to sequence bacteria species by species. A DNA test can't do that. What it can do is read the host genes that shape the terrain those bacteria live in, and how your body reacts to what they produce.
It can't tell you which bacterial species live in your gut, their relative abundance, or your microbiome's diversity score. That requires a stool sample and metagenomic sequencing, a different kind of test entirely.
It can read the host genes that shape the environment your gut bacteria live in, and how strongly your body reacts to what they produce, secretor status, lactose handling, histamine clearance, gut barrier strength, inflammatory tone. That's a genuinely useful, complementary layer of information.
Secretor status — shapes gut bacteria composition and B12 absorption
Lactase persistence — whether you keep digesting dairy into adulthood
Gut histamine clearance — sensitivity to fermented and aged foods
Cellular histamine clearance — complements DAO throughout the body
Vitamin D receptor — also regulates gut barrier tight junctions
Inflammatory cytokine — influences gut lining permeability
Master inflammatory regulator — central to gut barrier research and IBD treatment
FUT2, MCM6, DAO and HNMT are analysed as their own "Gut & Microbiome Genetics" section in the Ultimate report. VDR, IL6 and TNF are covered in the report's core vitamin D, bone health and inflammation findings.
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